CAS No. 2418670-70-7
Batch:
Purity:96.72
Chemical Structure
Check the
ML-SA5
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2418670-70-7 | |
|---|---|---|
| Molecular Formula |
C19H24ClN3O4S2 |
|
| Molecular Weight (MW) | 458.00 |
ML-SA5 is a potent synthetic agonist of the TRPML1 cation channel that activates endosomal TRPML1 currents. By stimulating TRPML1-mediated lysosomal calcium release, it effectively modulates endolysosomal trafficking, autophagic flux, and cellular clearance pathways. These lysosomal regulatory actions support its reported anticancer activity and highlight its therapeutic potential in managing lysosomal storage and muscular disorders.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.