CAS No. 577784-91-9

Batch: Purity:99.96
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ML-60218 Chemical Structure
Chemical Structure
Check the ML-60218 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-chloro-N-[3-(5-chloro-3-methyl-1-benzothiophen-2-yl)-1-methylpyrazol-5-yl]benzenesulfonamide
CAS Number 577784-91-9
Molecular Formula

C19H15Cl2N3O2S2
Molecular Weight (MW) 452.38
InChIKey BVBDTTLISMIOJY-UHFFFAOYSA-N

Ordering Information

Biological Activity

ML-60218 is a broad-spectrum inhibitor of RNA polymerase III (Pol III). By suppressing Pol III-mediated transcription of essential small non-coding RNAs, such as tRNAs and 5S rRNA, it disrupts cellular RNA synthesis pathways necessary for cell growth and metabolic maintenance. Additionally, ML-60218 alters viral replication complexes by disrupting pre-assembled viroplasms independently of cellular RNA transcription. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (198.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.