CAS No. 2070015-13-1
Batch:
Purity:99.91
Chemical Structure
Check the
ML241 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine;hydrochloride | |
|---|---|---|
| CAS Number | 2070015-13-1 | |
| Molecular Formula |
C23H25ClN4O
|
|
| Molecular Weight (MW) | 408.92 | |
| SMILES | C1CCC2=C(C1)C(=NC(=N2)N3CCOC4=CC=CC=C43)NCC5=CC=CC=C5.Cl | |
| InChIKey | DYHMHNNBOLCULH-UHFFFAOYSA-N |
ML241 hydrochloride is a potent and selective p97 inhibitor that targets p97 ATPase (IC50 0.11 μM) and suppresses Ub G76V –GFP degradation (IC50 3.5 μM). By disrupting p97-mediated protein quality control, it impairs endoplasmic reticulum-associated degradation and causes accumulation of polyubiquitinated protein substrates. This targeted inhibition alters ubiquitin-proteasome pathway signaling and suppresses cancer cell viability. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
74 mg/mL
(180.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.