CAS No. 423735-93-7
| IUPAC Name | 2-bromo-N-[3-(butanoylamino)phenyl]benzamide | |
|---|---|---|
| CAS Number | 423735-93-7 | |
| Molecular Formula |
C17H17BrN2O2 |
|
| Molecular Weight (MW) | 361.23 | |
| SMILES | CCCC(=O)NC1=CC(=CC=C1)NC(=O)C2=CC=CC=C2Br | |
| InChIKey | DFOVLSMXPWPCFH-UHFFFAOYSA-N |
ML161 (Parmodulin 2) is a selective allosteric inhibitor of protease-activated receptor 1 (PAR1). By targeting the intracellular domain of PAR1, it inhibits G protein-coupled downstream signaling pathways, suppressing thrombin-induced platelet aggregation and endothelial cell activation. Through this targeted mechanism, ML161 suppresses PAR1-driven vascular inflammation and thrombosis phenotypes without interfering with general thrombin catalytic activity. [1]
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Concentration
Volume
Mass
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|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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