CAS No. 1338934-59-0
| IUPAC Name | 7-hydroxy-6-methoxy-4-methyl-3-(2-morpholin-4-yl-2-oxoethyl)-2-oxochromene-8-carbaldehyde | |
|---|---|---|
| CAS Number | 1338934-59-0 | |
| Molecular Formula |
C18H19NO7 |
|
| Molecular Weight (MW) | 361.35 | |
| SMILES | CC1=C(C(=O)OC2=C(C(=C(C=C12)OC)O)C=O)CC(=O)N3CCOCC3 | |
| InChIKey | IFDGMRMUJYGWQQ-UHFFFAOYSA-N |
MKC8866 is a potent and selective IRE1α RNase inhibitor that suppresses the unfolded protein response (UPR) signaling pathway. By specifically blocking IRE1α endoribonuclease activity, MKC8866 prevents the downstream splicing of XBP1 mRNA, attenuating transcriptional activation of endoplasmic reticulum stress-response target genes. Consequently, inhibition of this pathway by MKC8866 disrupts tumor microenvironment crosstalk, decreases pro-survival signaling, and impairs cancer cell proliferation and survival in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(55.34 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.