CAS No. 1382799-40-7
Batch:
Purity:99.61
Chemical Structure
Check the
MK-8719
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-ethylimino-1,3a,5,6,7,7a-hexahydropyrano[3,2-d][1,3]thiazole-6,7-diol | |
|---|---|---|
| CAS Number | 1382799-40-7 | |
| Molecular Formula |
C9H14F2N2O3S |
|
| Molecular Weight (MW) | 268.28 | |
| SMILES | CCN=C1NC2C(C(C(OC2S1)C(F)F)O)O | |
| InChIKey | UDQTXCHQKHIQMH-KYGLGHNPSA-N |
MK-8719 is a potent and selective small-molecule inhibitor of human O-GlcNAcase (hOGA) with a Ki of. By blocking hOGA-mediated cleavage of O-linked N-acetylglucosamine modifications, MK-8719 increases hyper-O-GlcNAcylation of target proteins such as tau. This elevation in O-GlcNAcylation suppresses pathological tau aggregation and slows neurodegenerative disease progression in preclinical tauopathy models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(201.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 54 mg/mL |
| Ethanol | 54 mg/mL |
| Ethanol | 54 mg/mL |
| DMSO |
27 mg/mL
(100.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 14 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.