CAS No. 1030612-90-8
Batch:
Purity:99.10
Chemical Structure
Check the
MK-8245
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid | |
|---|---|---|
| CAS Number | 1030612-90-8 | |
| Molecular Formula |
C17H16BrFN6O4 |
|
| Molecular Weight (MW) | 467.25 | |
| SMILES | C1CN(CCC1OC2=C(C=CC(=C2)F)Br)C3=NOC(=C3)C4=NN(N=N4)CC(=O)O | |
| InChIKey | UJEAABFSXKCSGI-UHFFFAOYSA-N |
MK-8245 is a liver-targeted stearoyl-CoA desaturase inhibitor targeting human SCD1 (IC50 1 nM), rat SCD1, and mouse SCD1. By suppressing SCD1 activity in hepatic tissue, MK-8245 inhibits lipid biosynthesis and reduces desaturation indices specifically in the liver without affecting peripheral tissues. Consequently, it improves glucose clearance and ameliorates dyslipidemia in preclinical models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(199.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
93 mg/mL
(199.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.