CAS No. 935273-79-3
Batch:
Purity:99.33
Chemical Structure
Check the
MK-4101
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazole | |
|---|---|---|
| CAS Number | 935273-79-3 | |
| Molecular Formula |
C24H24F5N5O |
|
| Molecular Weight (MW) | 493.47 | |
| SMILES | CN1C(=NN=C1C23CCC(CC2)(CC3)C4=NOC(=N4)C5CC(C5)(F)F)C6=CC=CC=C6C(F)(F)F | |
| InChIKey | HKJOIWLYDJCTQR-UHFFFAOYSA-N |
MK-4101 is a potent inhibitor of the Hedgehog pathway that exhibits marked anti-tumor activity. By suppressing aberrant Hedgehog pathway activation, MK-4101 inhibits tumor cell proliferation and promotes extensive apoptosis in susceptible cell lines. Blockade of Hedgehog signaling downregulates downstream target gene expression, ultimately leading to cell cycle arrest and reduced cell viability across various cancer cell models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(198.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.