CAS No. 864388-65-8
Batch:
Purity:99.01
Chemical Structure
Check the
MK-28
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(E)-[(4,6-diphenylpyrimidin-2-yl)-methylhydrazinylidene]methyl]benzene-1,2-diol | |
|---|---|---|
| CAS Number | 864388-65-8 | |
| Molecular Formula |
C24H20N4O2 |
|
| Molecular Weight (MW) | 396.44 | |
| InChIKey | GKOVHCFOVLXKFL-PCLIKHOPSA-N |
Biological Activity
MK-28 is a potent and selective small-molecule activator of PERK (protein kinase R-like endoplasmic reticulum kinase). By stimulating PERK-mediated phosphorylation of eIF2α, MK-28 activates the unfolded protein response pathway to modulate translational control and cellular stress responses. Downstream PERK activation attenuates mutant huntingtin protein-induced cytotoxicity, rescuing striatal neurons from apoptotic cell death and promoting neuronal survival. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.