CAS No. 471905-41-6

Batch: Purity:99.21
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MK-0752 Chemical Structure
Chemical Structure
Check the MK-0752 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid
CAS Number 471905-41-6
Molecular Formula

C21H21ClF2O4S
Molecular Weight (MW) 442.9
SMILES C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
InChIKey XCGJIFAKUZNNOR-UHFFFAOYSA-N

Ordering Information

Biological Activity

MK-0752 is a potent γ-secretase inhibitor that blocks amyloid-β 40 (Aβ40) production with an IC50 ofin human SH-SY5Y cells. By inhibiting the γ-secretase complex, it suppresses the proteolytic cleavage of amyloid precursor protein (APP) and Notch receptors, thereby downregulating downstream Notch signaling. Consequently, MK-0752 reduces central nervous system levels of Aβ peptides and inhibits tumor-initiating cell self-renewal. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (200.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.