CAS No. 1445993-26-9

Batch: Purity:99.97
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Mivebresib (ABBV-075) Chemical Structure
Chemical Structure
Check the Mivebresib (ABBV-075) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide
CAS Number 1445993-26-9
Molecular Formula

C22H19F2N3O4S
Molecular Weight (MW) 459.47
SMILES CCS(=O)(=O)NC1=CC(=C(C=C1)OC2=C(C=C(C=C2)F)F)C3=CN(C(=O)C4=C3C=CN4)C
InChIKey RDONXGFGWSSFMY-UHFFFAOYSA-N

Ordering Information

Biological Activity

Mivebresib (ABBV-075) is a potent BET family bromodomain inhibitor that targets BRD2, BRD3, BRD4, and BRDT. By blocking BET bromodomain interaction with acetylated histones, it downregulates downstream oncogenic gene transcription including MYC and disrupts chromatin-dependent transcriptional signaling. Mivebresib efficiently triggers apoptosis and inhibits cell proliferation across various hematologic and solid tumor cell lines, displaying broad preclinical antitumor activity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (198.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.