CAS No. 1821370-28-8
Batch:
Purity:99.98
Chemical Structure
Check the
MitoPQ
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 10-[4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium-1-yl]decyl-triphenylphosphanium triiodide | |
|---|---|---|
| CAS Number | 1821370-28-8 | |
| Molecular Formula |
C39H46N2P.3I |
|
| Molecular Weight (MW) | 954.48 | |
| InChIKey | AOZZGHKENAZYTD-UHFFFAOYSA-K |
Biological Activity
MitoPQ (MitoParaquat) is a mitochondria-targeted redox cycler comprising a triphenylphosphonium cation conjugated to paraquat. Driven by the mitochondrial membrane potential, it selectively accumulates within the mitochondrial matrix and generates superoxide by redox cycling at the flavin site of complex I. This localized superoxide production modulates mitochondrial redox signaling, impairs respiratory function, and induces dose-dependent oxidative stress and cellular dysfunction in cell models. [1]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(104.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.