Mitomycin C Clinical Trials

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10mg	USD 197
50mg	USD 477

Clinical Trials

Numerous clinical trials evaluate Mitomycin C across diverse oncological and ophthalmological indications—including non-muscle invasive bladder cancer, glaucoma, corneal opacity, conjunctival intraepithelial neoplasia, and sarcomas—spanning Early Phase 1 through Phase 4. Sponsored by academic medical centers, collaborative research networks, and healthcare companies, these protocols reflect varied recruitment statuses, including completed, active, terminated, and pending studies. Specific evaluations encompass topical applications for ocular intraepithelial neoplasia as well as intravesical instillation strategies for high-risk bladder cancer.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04847063	RECRUITING	Peritoneal Mesothelioma; Peritoneal Carcinomatosis; Ovarian Cancer; Gastrointestinal Cancer; Appendiceal Cancer; Atypical Mesothelial Proliferation; Colorectal Cancer	National Cancer Institute (NCI)	2021-10-19	PHASE1
NCT07271355	NOT_YET_RECRUITING	Metastatic Appendix Carcinoma; Metastatic Colorectal Carcinoma; Metastatic Malignant Neoplasm in the Peritoneum; Stage IV Appendix Carcinoma AJCC v8; Stage IVC Colorectal Cancer AJCC v8; Unresectable Colorectal Carcinoma	City of Hope Medical Center	2026-10-01	PHASE3
NCT06211764	ACTIVE_NOT_RECRUITING	Non-Muscle Invasive Bladder Neoplasms	Janssen Research & Development, LLC	2024-04-09	PHASE3
NCT07475286	RECRUITING	Synchronous Gastric Peritoneal Carcinomatosis; Gastroesophageal Peritoneal Carcinomatosis	Mohammad Haroon Asif Choudry	2026-06-12	PHASE2
NCT07566156	RECRUITING	Urothelial Cancer; Urinary Bladder Neoplasms	Astellas Pharma Global Development, Inc.	2026-05-11	PHASE3
NCT07747740	RECRUITING	Non-Muscle-Invasive Bladder Cancer; BCG-Unresponsive Bladder Cancer	Blokhin's Russian Cancer Research Center	2026-07-09	PHASE2
NCT07671534	RECRUITING	Solid Tumor Cancer	Sarcoma Oncology Research Center, LLC	2026-06	PHASE2
NCT06781879	RECRUITING	Non-Muscle Invasive Bladder Cancer	Jakob Kristian Jakobsen	2025-06-01	PHASE4
NCT06207981	RECRUITING	Anal Cancer	Federation Francophone de Cancerologie Digestive	2024-02-26	PHASE3
NCT06513065	RECRUITING	Pseudomyxoma Peritonei	University of Southampton	2024-12-04	PHASE3
NCT07758881	NOT_YET_RECRUITING	Non-muscle Invasive Bladder Cancer (NMIBC)	Eight Medical International BV	2027-01
NCT06919965	RECRUITING	Non-Muscle Invasive Bladder Neoplasms	Janssen Research & Development, LLC	2025-09-10	PHASE3
NCT07487168	NOT_YET_RECRUITING	Peritoneal Carcinomatosis	H. Lee Moffitt Cancer Center and Research Institute	2026-08	PHASE1
NCT04779554	RECRUITING	Peritoneal Carcinomatosis	Prakash Pandalai	2021-06-04	PHASE2
NCT06388720	RECRUITING	Bladder Cancer	National Cancer Center, Korea	2024-11-19	PHASE2
NCT07504250	NOT_YET_RECRUITING	Dacryocystitis	All India Institute of Medical Sciences, Bhubaneswar	2026-04-01	PHASE4
NCT07189793	NOT_YET_RECRUITING	Urinary Bladder Neoplasms; Carcinoma, Transitional Cell; Carcinoma in Situ of Bladder; Non-Muscle-Invasive Bladder Cancer	First Affiliated Hospital of Wenzhou Medical University	2025-10	PHASE2
NCT07173023	NOT_YET_RECRUITING	Choanal Atresia	Assiut University	2025-09
NCT06696794	RECRUITING	Non-Muscle-Invasive Bladder Cancer (NMIBC)	Shaogang Wang	2025-02-17	PHASE3
NCT07646145	RECRUITING	Non-Muscle-Invasive Bladder Cancer (NMIBC)	Shanxi Province Cancer Hospital	2024-04-01	PHASE2
NCT04241185	ACTIVE_NOT_RECRUITING	Urinary Bladder Neoplasms	Merck Sharp & Dohme LLC	2020-05-19	PHASE3
NCT06233877	NOT_YET_RECRUITING	Pancreatic Cancer	Hirschfeld Oncology	2024-03-15	PHASE2
NCT05838391	RECRUITING	Anal Squamous Cell Carcinoma	Columbia University	2023-05-18
NCT06462001	ACTIVE_NOT_RECRUITING	Transitional Cell Carcinoma; Transurethral Resection	Nottingham University Hospitals NHS Trust	2020-12-10	PHASE3
NCT01815359	ACTIVE_NOT_RECRUITING	Appendix Cancer; Colorectal Cancer	Memorial Sloan Kettering Cancer Center	2013-03	PHASE2
NCT05902533	ACTIVE_NOT_RECRUITING	Anal Cancer	University of Cincinnati	2023-08-14	PHASE2; PHASE3
NCT06680245	NOT_YET_RECRUITING	Glaucoma	St. Joseph's Healthcare Hamilton	2024-12-01	PHASE3
NCT03648814	RECRUITING	Glaucoma, Neovascular; Vascular Endothelial Growth Factor Overexpression	Prince of Songkla University	2018-08-01
NCT02106572	TERMINATED	Superficial Bladder Cancer	Abnoba Gmbh	2015-04	PHASE3
NCT07754058	COMPLETED	Primary Acquired Nasolacrimal Duct Obstruction	Military Institute od Medicine National Research Institute	2023-07-18
NCT05688488	RECRUITING	Glottic Web of Larynx; Laryngeal Stenosis; Glottic Carcinoma; Laryngeal Leucoplakia; Laryngeal Polyp; Laryngeal Papilloma	Eye & ENT Hospital of Fudan University	2023-05-05	PHASE1; PHASE2
NCT02710734	COMPLETED	Urothelial Carcinoma of the Bladder	Fox Chase Cancer Center	2016-02-24	PHASE2
NCT03664869	UNKNOWN	Bladder Cancer	Turku University Hospital	2018-10-26	PHASE3
NCT05979909	NOT_YET_RECRUITING	Urothelial Carcinoma Ureter; Urothelial Cancer of Renal Pelvis	McMaster University	2023-09	PHASE1
NCT07034651	COMPLETED	Iris Diseases	Assiut University	2024-06-01
NCT06983704	COMPLETED	Pediatric Glaucoma	Benha University	2024-02-09	EARLY_PHASE1
NCT06944132	COMPLETED	Pterygium; Pterygium of the Conjunctiva and Cornea	Benha University	2024-04-01
NCT05544253	UNKNOWN	Hepatocellular Carcinoma; Peritoneal Metastasis; Hyperthymic; HCC	West China Hospital	2022-10-01	PHASE2; PHASE3
NCT04172675	COMPLETED	Urinary Bladder Neoplasms	Janssen Research & Development, LLC	2020-02-28	PHASE2
NCT03073694	UNKNOWN	Cancer, Appendiceal; ColoRectal Cancer	University of Kansas Medical Center	2017-07-14	PHASE2
NCT03844256	UNKNOWN	Urinary Bladder Cancer; Invasive Bladder Cancer	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2019-01-07	PHASE1; PHASE2
NCT06626802	COMPLETED	Esophageal Stricture	King Edward Medical University	2023-07-01
NCT03092518	COMPLETED	Gastric Adenocarcinoma; Esophagogastric Junction; Gastric Cancer	National Cancer Institute (NCI)	2017-06-05	PHASE2
NCT02614534	UNKNOWN	Colorectal Cancer	Maimónides Biomedical Research Institute of Córdoba	2015-11-16	PHASE3
NCT03330028	COMPLETED	Diseases of Oesophagus Stomach and Duodenum	M.D. Anderson Cancer Center	2017-10-27	PHASE1
NCT03548805	COMPLETED	Open Angle Glaucoma	L.V. Prasad Eye Institute	2018-08-16
NCT06000280	COMPLETED	Glaucoma	Universidade Federal de Goias	2021-01-04
NCT04811924	TERMINATED	Keratoconus	Ciusss de L'Est de l'Île de Montréal	2021-07-26	PHASE2
NCT05548478	UNKNOWN	Myopia	Al-Azhar University	2022-09
NCT06232005	COMPLETED	Urethral Stricture	Ain Shams University	2022-01-01	PHASE2; PHASE3
NCT05205122	UNKNOWN	Primary Congenital Glaucoma	Omar Abdelkarem Hasan	2022-02-01
NCT02030990	UNKNOWN	Corneal Opacity	United States Naval Medical Center, San Diego	2014-08	PHASE2; PHASE3
NCT03875911	TERMINATED	Glaucoma Open-Angle Primary; Glaucoma; Open Angle Glaucoma; Glaucoma, Open-Angle	University of California, Los Angeles	2019-03-30	PHASE4
NCT04735601	UNKNOWN	Glaucoma	Sohag University	2021-10-15	PHASE3
NCT02299999	ACTIVE_NOT_RECRUITING	Metastatic Breast Cancer	UNICANCER	2014-04-07	PHASE2
NCT02040142	COMPLETED	Peritoneal Carcinomatosis; Colorectal Cancer; Appendiceal Cancer; Peritoneal Mesothelioma; Pseudomyxoma Peritonei; Gastric Cancer	Albert Einstein College of Medicine	2011-11	PHASE2
NCT04747717	UNKNOWN	Ovarian Cancer	N.N. Petrov National Medical Research Center of Oncology	2020-10-01
NCT05627947	COMPLETED	Pterygium	Egymedicalpedia	2021-01-01	PHASE1
NCT02369458	COMPLETED	Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma, Head and Neck	Washington University School of Medicine	2015-04-14	PHASE2
NCT05586620	COMPLETED	Punctal Stenosis	Al-Azhar University	2021-06-01
NCT04200417	COMPLETED	Lung Metastases; Endobronchial Metastases; Pleural Metastases; Mediastinal Metastases	Memorial Sloan Kettering Cancer Center	2019-12-13	PHASE1
NCT04037072	WITHDRAWN	Esophageal Stenosis; Anastomotic Stenosis	Fox Chase Cancer Center	2020-04-03	PHASE2
NCT04493073	UNKNOWN	OCTA	Asmaa Ahmed Ali Youssif	2020-12-01	EARLY_PHASE1
NCT01675219	UNKNOWN	Bladder Cancer	Turku University Hospital	2012-12	PHASE3
NCT03658304	COMPLETED	Urothelial Carcinoma	University of Florida	2018-12-05	PHASE2
NCT03823989	COMPLETED	Cancer; Solid Tumor; Metastatic Disease	Lipomedix Pharmaceuticals Inc.	2019-01-03	PHASE1
NCT02695771	COMPLETED	Urinary Bladder Neoplasms	Corewell Health West	2016-04-19	PHASE3
NCT03924544	UNKNOWN	Primary Open-angle Glaucoma	Cairo University	2019-09-01	PHASE1
NCT04079725	UNKNOWN	Primary Congenital Glaucoma	Assiut University	2020-12
NCT04463901	UNKNOWN	Recurrent Pterygium	Sun Yat-sen University	2016-02
NCT02701088	COMPLETED	Locally Advanced Anal Canal Cancer	Centre Francois Baclesse	2015-12	PHASE2
NCT00666237	COMPLETED	Glaucoma	University of Miami	2008-04-01	PHASE4
NCT02088528	UNKNOWN	Glaucoma	Tema Christian Eye Center	2014-03
NCT03058757	COMPLETED	Bladder Cancer	National Cancer Center, Korea	2017-02-01	PHASE2
NCT03274024	UNKNOWN	Glaucoma	Singapore Eye Research Institute	2016-09-28
NCT03242317	UNKNOWN	Presbyopia	Fichte, Endl & Elmer Eyecare	2017-06-16	PHASE4
NCT03126877	UNKNOWN	Presbyopia	Whitten Laser Eye	2017-04-10	PHASE4
NCT02092298	COMPLETED	Gastrointestinal Cancer	M.D. Anderson Cancer Center	2014-05-08	PHASE2
NCT02805257	COMPLETED	Glaucoma; Primary Open Angle Glaucoma; Secondary Glaucoma; Neovascular Glaucoma	University of California, San Francisco	2016-06	PHASE2
NCT03335059	TERMINATED	Bladder Cancer; Bladder Neoplasm; Bladder Tumors; Cancer of Bladder; Cancer of the Bladder; Malignant Tumor of Urinary Bladder; Neoplasms, Bladder; Urinary Bladder Cancer; Carcinoma in Situ of Bladder; Papillary Carcinoma of Bladder (Diagnosis); BCG-Unresponsive Bladder Cancer	Medical Enterprises Ltd.	2019-04-04	PHASE3
NCT04934540	Recruiting	Bladder Cancer	Chinese University of Hong Kong	2020-01-01	--
NCT01905150	COMPLETED	Pancreatic Cancer	Bruckner Oncology	2014-08-13	PHASE2
NCT01621217	COMPLETED	Locally Advanced Cancer in the Anal Region	Lund University Hospital	2012-06	PHASE1
NCT02254915	WITHDRAWN	Urinary Bladder Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Neoplasms; Neoplasms by Site; Urinary Bladder Diseases; Urologic Diseases	Medical Enterprises Europe B.V.		PHASE3
NCT04419038	COMPLETED	Recurrent Pterygium of Eye	Menoufia University	2016-01-15
NCT03348969	COMPLETED	Bladder Cancer	Jørgen Bjerggaard Jensen	2017-11-01	PHASE4
NCT04352660	COMPLETED	Open Angle Glaucoma	University of California, San Diego	2016-05-23	PHASE4
NCT02744690	WITHDRAWN	Glaucoma	University of California, San Francisco	2015-03-01
NCT02471495	WITHDRAWN	Bladder Cancer	Medical Enterprises Europe B.V.	2016-09	PHASE3
NCT03381352	UNKNOWN	Anal Cancer	Chinese Academy of Medical Sciences	2015-12-02	PHASE2
NCT02994251	TERMINATED	Unresectable Intrahepatic Cholangiocarcinoma	Yale University	2017-06-21	PHASE2
NCT04011878	COMPLETED	Iris Disease	Assiut University	2016-01
NCT04284826	COMPLETED	Esophageal Stricture	Ajou University School of Medicine	2013-10-01
NCT02982395	TERMINATED	Non Muscle Invasive Bladder Cancer	Samyang Biopharmaceuticals Corporation	2017-01	PHASE3
NCT03101501	TERMINATED	Presbyopia	Key-Whitman Eye Center	2017-02-14	PHASE4
NCT01523275	TERMINATED	Laryngeal Stenosis; Subglottic Stenosis; Tracheal Stenosis	University of California, San Francisco	2012-08
NCT02075060	COMPLETED	Non Muscle-invasive Bladder Cancer	Poitiers University Hospital	2014-02-17
NCT02070120	UNKNOWN	Bladder Cancer	Institute of Cancer Research, United Kingdom	2014-10	PHASE2
NCT02471547	UNKNOWN	Transitional Cell Carcinoma	Sheba Medical Center	2016-01
NCT02989207	UNKNOWN	Primary Open Angle Glaucoma	Guy's and St Thomas' NHS Foundation Trust	2016-08
NCT02369939	UNKNOWN	Anal Carcinoma	University of Erlangen-Nürnberg Medical School	2014-12	PHASE3
NCT02102776	UNKNOWN	Pterygium	Sun Yat-sen University	2015-12
NCT02287389	UNKNOWN	Obstructive Airway Disease	Tang-Du Hospital	2014-12
NCT01705002	COMPLETED	Cancer; Solid Tumor; Metastatic Colorectal Cancer (mCRC)	Lipomedix Pharmaceuticals Inc.	2012-10	PHASE1
NCT01688024	UNKNOWN	Primary Sclerosing Cholangitis	Li, Zhiping, M.D.	2012-09	PHASE2
NCT01858025	COMPLETED	Carcinoma of the Anal Canal	Massachusetts General Hospital	2013-07	EARLY_PHASE1
NCT02560220	COMPLETED	Kidney Failure, Chronic	Heidelberg University	2015-08-05	PHASE1
NCT02016898	COMPLETED	Primary Open Angle Glaucoma	Duke University	2014-03	PHASE2
NCT02199327	COMPLETED	Conjunctival Intraepithelial Neoplasia; Corneal Intraepithelial Neoplasia	Coordinación de Investigación en Salud, Mexico	2014-05	PHASE4
NCT02641132	UNKNOWN	Pterygium	Meir Medical Center	2015-09	PHASE4
NCT01803295	COMPLETED	Carcinoma of Urinary Bladder, Superficial	UroGen Pharma Ltd.	2013-06
NCT02202044	TERMINATED	Bladder Carcinoma	University of Colorado, Denver	2015-02-24
NCT01017640	COMPLETED	Solid Neoplasm	National Cancer Institute (NCI)	2009-10	PHASE1
NCT02015650	TERMINATED	Head and Neck Neoplasms	Medical University Innsbruck	2014-04	PHASE4
NCT02307487	COMPLETED	Bladder Cancer; Neoplasms; Urinary Bladder Diseases; Urologic Diseases	UroGen Pharma Ltd.	2014-12	PHASE2
NCT02316171	COMPLETED	Non-muscle Invasive Bladder Cancer	Viralytics	2015-01-16	PHASE1
NCT03506542	COMPLETED	Glaucoma; Cataract; Wound Heal	Medical University of Lublin	2014-06-02	PHASE2
NCT01580410	COMPLETED	Carcinoma of the Appendix; Primary Peritoneal Cavity Cancer	Wake Forest University Health Sciences	2009-05	PHASE2
NCT01115517	COMPLETED	Pterygium	The University of Texas Health Science Center, Houston	2010-10	PHASE2
NCT03540953	TERMINATED	Esophageal Stenosis; Deglutition Disorders; Head and Neck Neoplasms; Esophageal Neoplasms	Fauze Maluf Filho	2015-01-05
NCT01324141	TERMINATED	Anal Cancer	National Cancer Institute (NCI)	2011-03-18	PHASE1
NCT00901108	TERMINATED	Open Angle Glaucoma	University of Alberta	2009-11	PHASE3
NCT02311101	COMPLETED	Urinary Bladder Neoplasm	The University of Texas Health Science Center at San Antonio	2012-03	PHASE1
NCT03694535	COMPLETED	Bladder Cancer	TC Erciyes University	2012-01-01
NCT02901236	COMPLETED	Glaucoma	Athens Vision Eye Institute	2014-01	PHASE2; PHASE3
NCT00661583	COMPLETED	Glaucoma	University of Colorado, Denver	2008-04	PHASE1; PHASE2
NCT03780868	COMPLETED	Primary Acquired Nasolacrimal Duct Obstruction	Menoufia University	2012-06-01
NCT01319721	COMPLETED	Recurrent Pterygium	Shiyou Zhou	2010-12
NCT02199327	Completed	Conjunctival Intraepithelial Neoplasia\|Corneal Intraepithelial Neoplasia	Coordinación de Investigación en Salud Mexico\|Instituto Mexicano del Seguro Social\|University of Guadalajara	2014-05	Phase 4
NCT02891460	COMPLETED	Urinary Bladder Neoplasms; Urologic Neoplasms; Neoplasms; Urinary Bladder Diseases; Urologic Diseases	UroGen Pharma Ltd.	2013-01
NCT01327521	WITHDRAWN	Carcinoma, Hepatocellular	Albert Koong	2011-02	PHASE3
NCT01296763	COMPLETED	Pancreatic Cancer	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	2011-01	PHASE1
NCT01263834	COMPLETED	Glaucoma	Prince of Songkla University	2010-12	PHASE2; PHASE3
NCT00854256	UNKNOWN	Glaucoma	University of Cologne	2009-04
NCT00384891	TERMINATED	Urinary Bladder Diseases; Urinary Bladder Neoplasms; Urinary Bladder Cancer; Malignant Tumor of Urinary Bladder; Urologic Diseases; Urologic Neoplasms; Neoplasms; Neoplasms by Site	Medical Enterprises Europe B.V.	2002-02	PHASE3
NCT01440751	COMPLETED	Glaucoma	Aeon Astron Europe B.V.	2011-09	PHASE4
NCT01530503	COMPLETED	Biliary Tract Cancer	IRCCS San Raffaele	2011-11	PHASE2
NCT00892398	COMPLETED	Glaucoma	Maisonneuve-Rosemont Hospital	2009-03
NCT01094964	UNKNOWN	Bladder Cancer	Cancer Research Campaign Clinical Trials Centre	2009-10	PHASE3
NCT00949182	COMPLETED	Liver Cancer	Rutgers, The State University of New Jersey	2009-07	PHASE2
NCT00183885	COMPLETED	Hepatocellular Carcinoma; Liver Cancer	University of Southern California	2004-10-18	PHASE2
NCT01648010	COMPLETED	Carcinoma of Urinary Bladder, Invasive	UroGen Pharma Ltd.	2011-11
NCT01200992	TERMINATED	Bladder Neoplasm; Neoplasm Recurrence, Local; Transitional Cell, Carcinoma; Carcinoma in Situ; Mycobacterium	Bioniche Life Sciences Inc.	2010-11	PHASE3
NCT01799499	WITHDRAWN	Non Muscle Invasive Bladder Cancer	UroGen Pharma Ltd.	2013-03
NCT01011010	COMPLETED	Liver Cancer	UNC Lineberger Comprehensive Cancer Center	2009-07-22	PHASE1
NCT01922154	COMPLETED	Glaucoma, Neovascular	Siriraj Hospital	2009-02	PHASE4
NCT01042782	COMPLETED	Advanced Gastric Cancer; Advanced Cancer of the Esophagogastric Junction	Krankenhaus Nordwest	2008-01	PHASE1
NCT00974818	TERMINATED	Bladder Cancer	Memorial Sloan Kettering Cancer Center	2009-09	PHASE3
NCT03176355	COMPLETED	Lacrimal Mucocele	Minia University	2011-03-23
NCT01167725	TERMINATED	Colorectal Cancer	Alliance for Clinical Trials in Oncology	2010-08	PHASE3
NCT01174420	UNKNOWN	Open-angle Glaucoma	Aeon Astron Europe B.V.	2009-11
NCT00524758	COMPLETED	Open Angle Glaucoma; Angle Closure Glaucoma; Uveitis Glaucoma; Young Age Glaucoma; Neovascular Glaucoma; High Risk Patient	Pro Top & Mediking Company Limited	2007-07	PHASE3
NCT00449098	UNKNOWN	Glaucoma	Pro Top & Mediking Company Limited	2007-01	PHASE4
NCT01039181	UNKNOWN	Advanced Intrahepatic Cholangiocarcinoma	National Science and Technology Development Agency, Thailand	2010-01	PHASE2
NCT00626782	COMPLETED	Glaucoma	Wills Eye	2008-01	PHASE2; PHASE3
NCT01226550	COMPLETED	Peritoneal Carcinosis (PC)	Hospices Civils de Lyon	2007-06	PHASE1; PHASE2
NCT01196455	UNKNOWN	Breast Cancer; Metastasis	Croatian Cooperative Group for Clinical Research in Oncology	2006-03	PHASE2
NCT00734994	COMPLETED	Transitional Cell Carcinoma of Bladder; Superficial Bladder Cancer	Mark Dewhirst	2008-04	EARLY_PHASE1
NCT00816075	UNKNOWN	Recurrent Superficial Bladder Cancer; Distilled Water	Bozyaka Training and Research Hospital	2009-02	PHASE2; PHASE3
NCT01042041	COMPLETED	Hepatocellular Carcinoma; Liver Cancer; Localized Unresectable Liver Cancer	Abramson Cancer Center at Penn Medicine	2009-09	PHASE1
NCT00538590	COMPLETED	Open Angle Glaucoma	Pro Top & Mediking Company Limited	2007-07	PHASE4
NCT00276744	TERMINATED	Pancreatic Cancer	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	2005-10	PHASE2
NCT00643877	UNKNOWN	Colorectal Neoplasms	Fudan University	2008-12	PHASE3
NCT01310764	COMPLETED	Glaucoma	Rassoul Akram Hospital	2009-04
NCT00318643	COMPLETED	Bladder Cancer	Halozyme Therapeutics	2006-03-30	PHASE1; PHASE2
NCT00201396	COMPLETED	Nasopharyngeal Carcinoma	National Health Research Institutes, Taiwan	2003-08	PHASE3
NCT00917657	COMPLETED	Hyperopia	University of Sao Paulo	2008-02
NCT00306852	COMPLETED	Glaucoma	University of Miami	1999-10
NCT00966056	COMPLETED	Nasal Synechiae; Adhesions of Nasal Cavity; Nasal Adhesions; Tissue Adhesions	Karnataka Institute of Medical Sciences	2007-10	PHASE2
NCT00644215	UNKNOWN	Bleb	Shahid Beheshti University of Medical Sciences	2007-06
NCT00423293	COMPLETED	Anal Cancer	Radiation Therapy Oncology Group	2006-12	PHASE2
NCT00597181	TERMINATED	Glaucoma	Indiana University	2007-11	PHASE4
NCT00551824	UNKNOWN	Esophageal Stricture; Caustic Esophageal Stricture; Peptic Esophageal Stricture; Post-Surgical Esophageal Stricture	Federal University of São Paulo	2007-10
NCT00271011	TERMINATED	Colorectal Cancer	University of Michigan Rogel Cancer Center	2005-12	PHASE2
NCT00967291	TERMINATED	Pancreatic Cancer	IRCCS San Raffaele	2006-03	PHASE2
NCT00492245	UNKNOWN	Keratitis; Corneal Opacity	Federal University of São Paulo	2006-04
NCT00472810	COMPLETED	Glaucoma; Trabeculectomy	Pro Top & Mediking Company Limited	2007-03	PHASE3
NCT00386399	WITHDRAWN	Pancreatic Cancer	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	2006-10	PHASE2
NCT00296322	COMPLETED	Stomach Cancer	Asan Medical Center	2001-10	PHASE3
NCT00068744	TERMINATED	Anal Cancer	European Organisation for Research and Treatment of Cancer - EORTC	2003-07	PHASE2; PHASE3
NCT00346489	COMPLETED	Glaucoma	Indiana University	2004-09	PHASE4
NCT00599950	TERMINATED	Refractive Disorders	Asociación para Evitar la Ceguera en México	2007-01	PHASE4
NCT00652860	COMPLETED	Metastatic Cancer; Sarcoma	Mayo Clinic	2001-08	PHASE2
NCT00201747	COMPLETED	Esophageal Cancer; Esophagus Cancer; Cancer of Stomach; Stomach Cancer	Ohio State University Comprehensive Cancer Center	2001-09	PHASE2
NCT00289445	COMPLETED	Gastrointestinal Neoplasms; Neoplasm Metastasis	University Hospital Tuebingen	1999-09	PHASE1; PHASE2
NCT00003596	COMPLETED	Anal Cancer	Radiation Therapy Oncology Group	1998-10	PHASE3
NCT00033644	TERMINATED	Sarcoma	Gynecologic Oncology Group	2002-03	PHASE2
NCT00265863	TERMINATED	Metastatic Cancer	Masonic Cancer Center, University of Minnesota	2004-08	PHASE2
NCT00023842	COMPLETED	Bladder Cancer	European Organisation for Research and Treatment of Cancer - EORTC	2001-06	PHASE2
NCT01920269	COMPLETED	Bladder Cancer TNM Staging Primary Tumor (T) Ta; Bladder Cancer TNM Staging Primary Tumor (T) T1; Bladder Cancer Transitional Cell Grade	University of Rome Tor Vergata	1994-01	PHASE2; PHASE3
NCT00042887	TERMINATED	Bladder Cancer	European Organisation for Research and Treatment of Cancer - EORTC	2002-05	PHASE3
NCT01149174	COMPLETED	Superficial Bladder Cancer	University of Rome Tor Vergata	1994-01	PHASE3
NCT00002507	COMPLETED	Carcinoma of Unknown Primary; Head and Neck Cancer	Yale University	1992-11	PHASE3
NCT00023868	TERMINATED	Colorectal Cancer; Metastatic Cancer	American College of Radiology Imaging Network	2001-11-01	PHASE3
NCT01442519	COMPLETED	Bladder Cancer	University of Rome Tor Vergata	1994-01	PHASE3
NCT00003018	COMPLETED	Pancreatic Cancer	SWOG Cancer Research Network	1997-09	PHASE2
NCT00003710	COMPLETED	Unspecified Adult Solid Tumor, Protocol Specific	The University of Texas Health Science Center at San Antonio	1998-08	PHASE1
NCT00005944	TERMINATED	Colorectal Cancer; Metastatic Cancer; Primary Peritoneal Cavity Cancer	UNICANCER	1999-07-01	PHASE2
NCT00003003	COMPLETED	Leukemia	Dartmouth-Hitchcock Medical Center	1996-09	PHASE1
NCT00002993	TERMINATED	Sarcoma	Gynecologic Oncology Group	1997-08	PHASE2
NCT00003209	COMPLETED	Cervical Cancer	European Organisation for Research and Treatment of Cancer - EORTC	1997-12	PHASE3
NCT00415077	TERMINATED	MODERATE AND HIGH MYOPIA	Walter Reed Army Medical Center	2004-06
NCT00003240	UNKNOWN	Lung Cancer	National Cancer Institute (NCI)	1995-10	PHASE3
NCT00024271	UNKNOWN	Malignant Mesothelioma	Herbert Irving Comprehensive Cancer Center	2001-05	PHASE2
NCT00564213	COMPLETED	High Myopia	Instituto de Olhos de Goiania	2005-03	PHASE4
NCT00005870	UNKNOWN	Pancreatic Cancer	Astex Pharmaceuticals, Inc.	1999-03	PHASE3
NCT00918528	UNKNOWN	Urethral Stricture	Hillel Yaffe Medical Center	2009-06	PHASE1; PHASE2
NCT00006112	UNKNOWN	Carcinoma of the Appendix; Colorectal Cancer; Primary Peritoneal Cavity Cancer	Gustave Roussy, Cancer Campus, Grand Paris	1996-01	PHASE2
NCT00004209	UNKNOWN	Lung Cancer	Cancer Research UK	1998-05	PHASE3
NCT00005825	UNKNOWN	Lung Cancer	Raghu Nandan, M.D., Inc	1998-09	PHASE2
NCT00128037	COMPLETED	Pulmonary Neoplasm	Japan Clinical Oncology Group	1999-05	PHASE2
NCT00192049	COMPLETED	Superficial Bladder Cancer	Eli Lilly and Company	2003-12	PHASE2
NCT00003893	COMPLETED	Breast Cancer	University Hospital Birmingham	1998-07	PHASE3
NCT00294359	COMPLETED	Metastatic Colorectal Cancer	Australasian Gastro-Intestinal Trials Group	2005-06	PHASE2; PHASE3
NCT00003159	COMPLETED	Lung Cancer	Medical Research Council	1997-08	PHASE3
NCT00893490	UNKNOWN	Refractory Glaucoma	Shahid Beheshti University of Medical Sciences		PHASE1
NCT00371072	COMPLETED	Pediatric Aphakic Glaucoma	Shahid Beheshti University of Medical Sciences	2004-03	PHASE2; PHASE3
NCT00999973	UNKNOWN	Myopia	Shahid Beheshti University of Medical Sciences	2009-09	PHASE1
NCT00004887	UNKNOWN	Lung Cancer	The Christie NHS Foundation Trust	1999-01	PHASE3
NCT01504282	COMPLETED	Myopia	Shahid Beheshti University of Medical Sciences
NCT00025090	COMPLETED	Anal Cancer	University College London (UCL) Cancer Institute	2001-03	PHASE3
NCT00075699	COMPLETED	Malignant Mesothelioma	Medical Research Council	2003-09	PHASE3
NCT00024349	COMPLETED	Bladder Cancer	University Hospital Birmingham	2001-06	PHASE3
NCT00002490	COMPLETED	Bladder Cancer	Medical Research Council	1991-09	PHASE3
NCT00030459	UNKNOWN	Malignant Mesothelioma	British Thoracic Society	2000-11	PHASE2
NCT00468429	UNKNOWN	Glaucoma	Grewal Eye Institute	2007-05	PHASE4

(data from https://clinicaltrials.gov, updated on 2026-08-25)

Check the Mitomycin C product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Mitomycin C functions by alkylating and cross-linking DNA to inhibit DNA synthesis, subsequently triggering cell death via caspase-dependent and Fas/CD95-independent apoptotic pathways. This targeted cytotoxicity suppresses abnormal cellular proliferation, thereby inhibiting tumor progression in clinical conditions such as non-muscle invasive bladder cancer and ocular intraepithelial neoplasia.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).