CAS No. 2361564-49-8

Batch: Purity:
Mito-LND (Mito-Lonidamine) Chemical Structure
Chemical Structure
Check the Mito-LND (Mito-Lonidamine) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 10-[[1-[(2,4-dichlorophenyl)methyl]indazole-3-carbonyl]amino]decyl-triphenylphosphanium bromide
CAS Number 2361564-49-8
Molecular Formula

C43H45Cl2N3OP.Br
Molecular Weight (MW) 801.62
SMILES O=C(NCCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=NN(CC5=CC=C(Cl)C=C5Cl)C6=C4C=CC=C6.[Br-]
InChIKey XRSSFQSESARZNG-UHFFFAOYSA-N

Biological Activity

Mito-LND (Mito-Lonidamine) is a mitochondria-targeted oxidative phosphorylation (OXPHOS) inhibitor. Driven by high mitochondrial membrane potential in cancer cells, it selectively accumulates in mitochondria to disrupt respiratory complexes I and II. This action stimulates reactive oxygen species (ROS) production and peroxiredoxin 3 (Prx3) oxidation, leading to suppression of AKT/mTOR/p70S6K signaling and inhibition of tumor cell proliferation.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.