CAS No. 862189-95-5
Batch:
Purity:98.03
Chemical Structure
Check the
Mirodenafil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-3H-pyrrolo[3,2-d]pyrimidin-4-one | |
|---|---|---|
| CAS Number | 862189-95-5 | |
| Molecular Formula |
C26H37N5O5S |
|
| Molecular Weight (MW) | 531.67 | |
| InChIKey | MIJFNYMSCFYZNY-UHFFFAOYSA-N |
Biological Activity
Mirodenafil (SK3530) is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). By blocking PDE5-mediated hydrolysis of cyclic guanosine monophosphate (cGMP), it prevents cGMP degradation, leading to elevated intracellular cGMP levels. This accumulation downstream activates protein kinase G (PKG) and promotes smooth muscle relaxation in vascular tissues, thereby enhancing erectile responses in preclinical models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(188.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.