CAS No. 862189-96-6

Batch: Purity:99.93
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Mirodenafil Dihydrochloride Chemical Structure
Chemical Structure
Check the Mirodenafil Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-3H-pyrrolo[3,2-d]pyrimidin-4-one;dihydrochloride
CAS Number 862189-96-6
Molecular Formula

C26H37N5O5S.2ClH
Molecular Weight (MW) 604.59
SMILES Cl.Cl.CCCOC1=C(C=C(C=C1)[S;v6](=O)(=O)N2CCN(CCO)CC2)C3=NC(=O)C4=C(N3)C(=C[N]4CC)CCC
InChIKey CKPHITUXXABKDL-UHFFFAOYSA-N

Biological Activity

Mirodenafil Dihydrochloride (SK-3530 dihydrochloride) is a potent, orally active phosphodiesterase type 5 (PDE5) inhibitor developed for the treatment of erectile dysfunction. By inhibiting PDE5, it prevents the degradation of cyclic guanosine monophosphate (cGMP), leading to elevated intracellular cGMP levels in vascular smooth muscle cells. This enhances nitric oxide-mediated signaling, inducing relaxation of corpus cavernosum smooth muscle and facilitating vascular vasodilation.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (165.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 13 mg/mL
Water 1 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.