CAS No. 1198097-97-0

Batch: Purity:99.79
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Mirin Chemical Structure
Chemical Structure
Check the Mirin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (5Z)-2-amino-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one
CAS Number 1198097-97-0
Molecular Formula

C10H8N2O2S
Molecular Weight (MW) 220.25
SMILES OC1=CC=C(C=C1)\C=C2/SC(=N)NC2=O
InChIKey YBHQCJILTOVLHD-YVMONPNESA-N

Ordering Information

Biological Activity

Mirin is a small-molecule inhibitor of the Mre11-Rad50-Nbs1 (MRN) complex that specifically suppresses Mre11-associated exonuclease activity. By preventing MRN-dependent activation of ATM kinase, Mirin blocks downstream DNA damage response signaling pathways. Consequently, cellular treatment with Mirin impairs double-strand break end resection, prevents homologous recombination, and disrupts DNA damage-induced cell cycle checkpoint activation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 44 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.