CAS No. 1313881-70-7

Batch: Purity:99.45
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Miransertib (ARQ-092) Chemical Structure
Chemical Structure
Check the Miransertib (ARQ-092) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
CAS Number 1313881-70-7
Molecular Formula

C27H24N6
Molecular Weight (MW) 432.52
SMILES C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
InChIKey HNFMVVHMKGFCMB-UHFFFAOYSA-N

Biological Activity

Miransertib (ARQ-092) is a potent, selective, and orally bioavailable allosteric AKT inhibitor targeting AKT1, AKT2, and AKT3. By preventing AKT membrane localization and activation, it inhibits downstream AKT/mTOR pathway signaling, suppressing cellular proliferation and inducing apoptosis in cancer cells harboring PIK3CA or AKT mutations.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 8 mg/mL (18.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.