CAS No. 180064-38-4

Batch: Purity:99.68
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Minodronic acid Chemical Structure
Chemical Structure
Check the Minodronic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 180064-38-4
Molecular Formula

C9H12N2O7P2
Molecular Weight (MW) 322.15
SMILES C1=CC2=NC=C(N2C=C1)CC(O)(P(=O)(O)O)P(=O)(O)O

Biological Activity

Minodronic acid (YM529) is a third-generation nitrogen-containing bisphosphonate that acts as a potent inhibitor of farnesyl pyrophosphate synthase and selectively targets purinergic P2X2/3 receptors. By inhibiting farnesyl pyrophosphate synthase, it suppresses protein prenylation within the mevalonate pathway, leading to osteoclast inactivation and apoptosis. Consequently, minodronic acid reduces bone resorption, prevents osteolytic bone destruction, and attenuates bone pain in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
0.5MNAOH 3.06 mg/mL
DMSO 0.001 mg/mL (0.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] J. Med. Chem. 2001;44(20):3338-3338.

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Note: Technical data last updated: Sep 1, 2026.