CAS No. 76541-72-5
Batch:
Purity:99.78
Chemical Structure
Check the
Mifobate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl phosphate | |
|---|---|---|
| CAS Number | 76541-72-5 | |
| Molecular Formula |
C11H17ClO7P2 |
|
| Molecular Weight (MW) | 358.65 | |
| SMILES | COP(=O)(C(C1=CC=C(C=C1)Cl)OP(=O)(OC)OC)OC | |
| InChIKey | VQHUQHAPWMNBLP-UHFFFAOYSA-N |
Mifobate acts as a peroxisome proliferator-activated receptor gamma (PPARγ) antagonist that selectively inhibits thiazolidinedione-induced PPARγ transcriptional activity. By targeting the PPARγ nuclear receptor, it disrupts ligand-mediated transcriptional activation and downstream pathway signaling. This antagonism alters PPARγ-regulated gene networks involved in adipocyte differentiation, lipid metabolism, and glucose homeostasis, thereby serving as a useful tool for investigating PPARγ-dependent cellular functions and metabolic processes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 72 mg/mL |
| Ethanol | 72 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.