CAS No. 84371-65-3

Batch: Purity:100.00
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Mifepristone (RU-486) Chemical Structure
Chemical Structure
Check the Mifepristone (RU-486) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number 84371-65-3
Molecular Formula

C29H35NO2
Molecular Weight (MW) 429.59
SMILES CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O
InChIKey VKHAHZOOUSRJNA-GCNJZUOMSA-N

Ordering Information

Biological Activity

Mifepristone (RU-486) is a synthetic steroid acting as a potent antagonist of the progesterone receptor and glucocorticoid receptor. By competitively binding to these receptors, mifepristone inhibits progestin and glucocorticoid signaling pathways, blocking receptor-mediated gene transcription. This inhibition suppresses cell survival pathways, promoting autophagy and apoptosis in targeted cell lines. Mifepristone is widely utilized to investigate nuclear receptor signaling mechanisms in reproductive and endocrine research models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (197.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 85 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.