CAS No. 1303607-60-4
Batch:
Purity:99.68
Chemical Structure
Check the
SAR405838
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | |
|---|---|---|
| CAS Number | 1303607-60-4 | |
| Molecular Formula |
C29H34Cl2FN3O3 |
|
| Molecular Weight (MW) | 562.50 | |
| SMILES | CC(C)(C)CC1C2(C(C(N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O | |
| InChIKey | IDKAKZRYYDCJDU-AEPXTFJPSA-N |
Biological Activity
SAR405838 is an orally available MDM2 antagonist (Ki 0.88 nM) that selectively inhibits the MDM2-p53 interaction. By disrupting MDM2 binding, SAR405838 blocks p53 degradation and restores p53 transcriptional activity. This leads to the upregulation of downstream target genes such as p21 and PUMA, driving robust cell cycle arrest and apoptosis in p53 wild-type tumor cells.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(177.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 31 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(177.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 31 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.