CAS No. 1271738-62-5
Batch:
Purity:99.96
Chemical Structure
Check the
MI-2 (Menin-MLL Inhibitor)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine | |
|---|---|---|
| CAS Number | 1271738-62-5 | |
| Molecular Formula |
C18H25N5S2 |
|
| Molecular Weight (MW) | 375.55 | |
| SMILES | CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C | |
| InChIKey | SRQYLNYQAPCPIR-UHFFFAOYSA-N |
MI-2 is a potent inhibitor of the menin-MLL interaction with an IC50 of. By disruptively binding to menin, MI-2 blocks its association with MLL fusion proteins, resulting in the downregulation of critical downstream target genes such as HOXA9 and MEIS1. This inhibition suppresses cellular proliferation, impairs self-renewal, and induces cell differentiation and apoptosis in MLL-rearranged leukemia models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 75 mg/mL |
| Water | Insoluble |
| DMSO |
75 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 75 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- MI-2 (Menin-MLL Inhibitor) Clinical Trials
- MI-2 (Menin-MLL Inhibitor) Solubility in DMSO
- MI-2 (Menin-MLL Inhibitor) Stock Solution
- MI-2 (Menin-MLL Inhibitor) Storage
- MI-2 (Menin-MLL Inhibitor) Stability
- MI-2 (Menin-MLL Inhibitor) Molecular Weight
- MI-2 (Menin-MLL Inhibitor) SMILES
- MI-2 (Menin-MLL Inhibitor) Chemical Structure (2D and 3D)
- MI-2 (Menin-MLL Inhibitor) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.