CAS No. 1047953-91-2

Batch: Purity:99.93
Check CoA
MI-2 (MALT1 inhibitor) Chemical Structure
Chemical Structure
Check the MI-2 (MALT1 inhibitor) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1,2,4-triazol-1-yl]phenyl]acetamide
CAS Number 1047953-91-2
Molecular Formula

C19H17Cl3N4O3
Molecular Weight (MW) 455.72
SMILES COCCOC1=NN(C(=N1)C2=CC(=C(C=C2)Cl)Cl)C3=CC=C(C=C3)NC(=O)CCl
InChIKey TWJGQZBSEMDPQP-UHFFFAOYSA-N

Biological Activity

MI-2 is an irreversible small-molecule MALT1 inhibitor that directly binds to the MALT1 active site. By blocking MALT1 paracaspase protease cleavage of downstream substrates, MI-2 disrupts canonical NF-kB signaling. This targeted inhibition leads to reduced expression of NF-kB target genes and induces selective apoptosis in activated B-cell-like diffuse large B-cell lymphoma cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 91 mg/mL (199.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 91 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Fontan L, et al. Cancer Cell. 2012;22(6):812-24.

Jump to

Note: Technical data last updated: Sep 1, 2026.