CAS No. 27406-31-1
Batch:
Purity:99.97
Chemical Structure
Check the
MHY-1685
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[(4-hydroxyphenyl)methylidene]-1,3-diazinane-2,4,6-trione | |
|---|---|---|
| CAS Number | 27406-31-1 | |
| Molecular Formula |
C11H8N2O4 |
|
| Molecular Weight (MW) | 232.19 | |
| SMILES | OC1=CC=C(C=C1)C=C2C(=O)NC(=O)NC2=O | |
| InChIKey | KSOJQSBHVKAHPC-UHFFFAOYSA-N |
Biological Activity
MHY-1685 is a novel synthetic small-molecule inhibitor of mammalian target of rapamycin (mTOR). By targeting the mTOR signaling pathway, MHY-1685 promotes autophagy and attenuates cellular senescence in human cardiac stem cells. Downstream inhibition of mTOR disrupts nutrient-sensing cascades and reduces senescence-associated cell cycle arrest, restoring cellular homeostasis and functional capacity in progenitor cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
46 mg/mL
(198.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.