CAS No. 875337-44-3

Batch: Purity:99.39
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MGCD-265 analog Chemical Structure
Chemical Structure
Check the MGCD-265 analog product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]carbamothioyl]-2-phenylacetamide
CAS Number 875337-44-3
Molecular Formula

C26H20FN5O2S2
Molecular Weight (MW) 517.60
SMILES CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F
InChIKey UFICVEHDQUKCEA-UHFFFAOYSA-N

Ordering Information

Biological Activity

MGCD-265 analog is an ATP-competitive, multi-targeted receptor tyrosine kinase inhibitor targeting c-Met, VEGFR1, VEGFR2, VEGFR3, Ron, and Tie2. By inhibiting c-Met and VEGFR kinase activity, it blocks downstream signaling pathways vital for endothelial and cancer cell function. This targeted inhibition effectively impairs tumor cell proliferation, survival, and motility while suppressing blood vessel formation and tumor angiogenesis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 104 mg/mL (200.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.