CAS No. 133407-82-6

Batch: Purity:99.47
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MG132 SSS Chemical Structure
Chemical Structure
Check the MG132 SSS product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
CAS Number 133407-82-6
Molecular Formula

C26H41N3O5
Molecular Weight (MW) 475.62
InChIKey TZYWCYJVHRLUCT-VABKMULXSA-N

Ordering Information

Biological Activity

MG132 SSS (Z-Leu-Leu-Leu-al) is a potent synthetic peptide aldehyde inhibitor of the proteasome and calpain. By suppressing the catalytic peptidase activity of the 20S and 26S proteasome complexes, MG132 SSS prevents ubiquitin-conjugated protein degradation within the ubiquitin-proteasome pathway. This proteasomal blockade disrupts cellular protein turnover, prevents activation of the NF-kB pathway, alters antigen presentation on MHC class I molecules, and triggers cell cycle arrest or apoptosis in targeted cell models.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 95 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.