CAS No. 694488-83-0
Batch:
Purity:99.19
Chemical Structure
Check the
MFI8
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-chloro-2-[1-(2,3-dimethylanilino)ethyl]phenol | |
|---|---|---|
| CAS Number | 694488-83-0 | |
| Molecular Formula |
C16H18ClNO |
|
| Molecular Weight (MW) | 275.77 | |
| InChIKey | DYILWFVSLLZIIR-UHFFFAOYSA-N |
Biological Activity
MFIis a small-molecule inhibitor of mitofusin-1 (MFN1) and mitofusin-2 (MFN2). By targeting mitofusins to disrupt tethering and oligomerization, MFIinhibits mitochondrial fusion and decreases the mitochondrial aspect ratio, promoting mitochondrial fragmentation and reducing organelle functionality. Downstream, MFIinduces minority mitochondrial outer membrane permeabilization and caspase-3/activation, enhancing cell death in combination with SMAC mimetics. Additionally, MFIsuppresses mitophagy and mitochondria-ER interactions, sensitizing leukemia cells to BH3 mimetics. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(199.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 55 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.