CAS No. 1050656-06-8
Batch:
Purity:99.8
Chemical Structure
Check the
MF-766
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[1-[[1-[[4-(trifluoromethyl)phenyl]methyl]indole-7-carbonyl]amino]cyclopropyl]benzoic acid | |
|---|---|---|
| CAS Number | 1050656-06-8 | |
| Molecular Formula |
C27H21F3N2O3 |
|
| Molecular Weight (MW) | 478.46 | |
| InChIKey | BWXAZFCPGFKANL-UHFFFAOYSA-N |
MF-766 is an orally active, potent, and selective prostaglandin E2 receptor 4 (EP4) antagonist (Ki 0.23 nM). Blockade of EP4 signaling by MF-766 inhibits PGE2-mediated immune suppression, promoting the infiltration of CD8+ T cells, natural killer cells, and dendritic cells into the tumor microenvironment. This antagonism restores cytokine production, including interferon-γ, and remodels tumor-associated myeloid cell populations to enhance anti-tumor immunity. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(200.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.