CAS No. 921605-87-0
Batch:
Purity:99.94
Chemical Structure
Check the
MF-438
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole | |
|---|---|---|
| CAS Number | 921605-87-0 | |
| Molecular Formula |
C19H18F3N5OS |
|
| Molecular Weight (MW) | 421.44 | |
| SMILES | CC1=NN=C(S1)C2=NN=C(C=C2)N3CCC(CC3)OC4=CC=CC=C4C(F)(F)F | |
| InChIKey | NVUJDKDVOZVALT-UHFFFAOYSA-N |
MF-438 is a potent, orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 ofagainst rat SCD1 (rSCD1). It blocks the conversion of saturated fatty acids into monounsaturated fatty acids, disrupting lipid biosynthesis and altering membrane lipid homeostasis. This targeted inhibition disrupts downstream lipid signaling pathways, reduces cellular monounsaturated fatty acid pools, and suppresses cancer cell proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(71.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
| DMSO |
30 mg/mL
(71.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.