CAS No. 98418-47-4

Batch: Purity:99.99
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Metroprolol succinate Chemical Structure
Chemical Structure
Check the Metroprolol succinate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 98418-47-4
Molecular Formula

C34H56N2O10
Molecular Weight (MW) 652.82
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(CC(=O)O)C(=O)O

Ordering Information

Biological Activity

Metoprolol succinate is a cardioselective, competitive beta-1 adrenergic receptor antagonist devoid of intrinsic sympathomimetic activity. By selectively inhibiting beta-1 adrenergic receptors, it blocks endogenous catecholamine binding and inhibits downstream cyclic adenosine monophosphate (cAMP) signaling pathways. This inhibition reduces intracellular calcium influx in cardiac myocytes, ultimately suppressing heart rate, myocardial contractility, and cardiac conduction velocity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (153.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 5 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.