Clinical Trials

Numerous clinical trials evaluate metoprolol across Phase 1 through Phase 4 and non-interventional studies, focusing on conditions such as heart failure, hypertension, atrial fibrillation, and COVID-19 pneumonia. Sponsored by pharmaceutical corporations as well as academic and hospital centers, these studies encompass various recruitment statuses, including completed, recruiting, and terminated. Research scopes range from assessing treatment quality and guideline adherence to comparing 24-hour blood pressure reductions between anti-hypertensive regimens.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06964464 RECRUITING
Heart Failure With Reduced Ejection Fraction (HFrEF); Sudden Cardiac Death; Ventricular Arrhythmia; Implantable Cardioverter Defibrillator (ICD); Beta-blocker Therapy; Cardiomyopathy
University of Rochester
 2025-08-17 PHASE4
NCT07519161 NOT_YET_RECRUITING
Atrial Fibrillation
Shanghai East Hospital
 2026-04-07
NCT07490067 RECRUITING
Heart Failure With Reduced Ejection Fraction
University of Michigan
 2026-10 PHASE4
NCT07445789 NOT_YET_RECRUITING
Atrial Fibrillation (AF)
Martini Hospital Groningen
 2026-06 PHASE4
NCT07632157 NOT_YET_RECRUITING
Atrial Flutter With Rapid Ventricular Response
Wake Forest University Health Sciences
 2026-10 PHASE3
NCT07755904 NOT_YET_RECRUITING
Cardiomyopathy, Hypertrophic Obstructive
Braveheart Bio, Inc.
 2026-10 PHASE3
NCT07268170 ENROLLING_BY_INVITATION
Coronary Arterial Disease (CAD); Ischemic Heart Disease (IHD)
Gødstrup Hospital
 2025-12-15 PHASE2; PHASE3
NCT07568574 ENROLLING_BY_INVITATION
Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes
Enhanced Emirates Limited
 2026-03-12
NCT06825728 NOT_YET_RECRUITING
Heart Failure With Reduced Ejection Fraction (HFrEF); COPD (Chronic Obstructive Pulmonary Disease)
Xiangya Hospital of Central South University
 2025-02 PHASE4
NCT07706075 NOT_YET_RECRUITING
Atrial Fibrillation (AF); Atrial Fibrillation With Rapid Ventricular Response
Muhammad Ali Javed
 2027-01-01 PHASE4
NCT07597564 NOT_YET_RECRUITING
General Anesthesia; Tracheal Intubation
Fujian Provincial Hospital
 2026-06-22 PHASE4
NCT06967194 RECRUITING
ST Segment Elevation Myocardial Infarction (STEMI); Cardiogenic Shock Post Myocardial Infarction
Tel-Aviv Sourasky Medical Center
 2025-05-21
NCT05931276 RECRUITING
End-Stage Kidney Disease; End-Stage Renal Disease
VA Office of Research and Development
 2024-05-22 PHASE3
NCT06569212 RECRUITING
Non-Traumatic Subarachnoid Hemorrhage
Madeleine Puissant
 2024-09-23 PHASE4
NCT07103655 NOT_YET_RECRUITING
Hypertrophic Cardiomyopathy (HCM)
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2026-01-01 PHASE4
NCT05631730 RECRUITING
Mitral Valve Prolapse; Ventricular Arrhythmias and Cardiac Arrest
Oslo University Hospital
 2023-01-04 PHASE3
NCT06035978 UNKNOWN
Cardiovascular Diseases; Heart Failure With Reduced Ejection Fraction
University Hospital Ostrava
 2024-03 PHASE4
NCT04914234 RECRUITING
Hypotension Drug-Induced
Damanhour Teaching Hospital
 2025-08-01 PHASE4
NCT06879769 RECRUITING
Coronary Computed Tomography Angiography; Contrast Media; Cardiac Output
Karolinska University Hospital
 2021-01-01
NCT06864234 RECRUITING
Coronary Arterial Disease (CAD); Angina (Stable); Microvascular Circulation
VZW Cardiovascular Research Center Aalst
 2025-07-03 PHASE4
NCT03566667 COMPLETED
Chronic Obstructive Pulmonary Disease
Ole Frobert, MD, PhD
 2018-06-12 PHASE4
NCT06686628 COMPLETED
Dermatitis Atopic
Sanofi
 2024-11-20 PHASE1
NCT05847517 TERMINATED
Acute Respiratory Distress Syndrome (ARDS)
Consorcio Centro de Investigación Biomédica en Red (CIBER)
 2024-07-10 PHASE3
NCT01608893 UNKNOWN
Atrial Fibrillation
University of Calgary
 2012-05
NCT06808802 COMPLETED
Healthy
Eli Lilly and Company
 2025-02-03 PHASE1
NCT03778554 ACTIVE_NOT_RECRUITING
Acute Myocardial Infarction; Non-ST Elevation Myocardial Infarction (nSTEMI); ST Elevation Myocardial Infarction
Bispebjerg Hospital
 2018-12-17 PHASE4
NCT05546320 COMPLETED
Patent Foramen Ovale; Migraine
Chinese Academy of Medical Sciences, Fuwai Hospital
 2022-10-15 PHASE2
NCT05767346 COMPLETED
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Cytokinetics
 2023-06-20 PHASE3
NCT04434664 COMPLETED
Heart Failure With Preserved Ejection Fraction; Hypertension
University of Pennsylvania
 2021-12-01 PHASE4
NCT07568873 COMPLETED
Stress Response of Endotracheal Intubation and Surgical Field Clarity in FESS
Zagazig University
 2024-01-25
NCT05891119 COMPLETED
Atopic Dermatitis
Amgen
 2023-06-03 EARLY_PHASE1
NCT05741385 COMPLETED
Liver Cirrhosis
Boehringer Ingelheim
 2023-10-10
NCT07378228 COMPLETED
Coronary Heart Disease; Stable Angina Pectoris
Xikun Li
 2023-07-01
NCT06357104 COMPLETED
COVID-19 Vaccine Adverse Reaction
Pachankis, Yang I., M.D.
 2024-02-26 PHASE4
NCT05745337 UNKNOWN
Atrial Fibrillation; Diastolic Dysfunction; HFpEF - Heart Failure With Preserved Ejection Fraction
University of Vermont
 2023-02-06 PHASE1
NCT03070184 COMPLETED
Healthy; Pre Hypertension
University of Alabama at Birmingham
 2017-04-30 PHASE2
NCT06592547 COMPLETED
Septic Shock; Ventilator Acquired Pneumonia
Alexandria University
 2022-04-01 PHASE2
NCT03278509 UNKNOWN
Acute Myocardial Infarction; Non-ST Elevation Myocardial Infarction; ST Elevation Myocardial Infarction
Karolinska Institutet
 2017-09-11 PHASE4
NCT05096884 TERMINATED
Tachycardia; Dyspnea; COVID-19
Hackensack Meridian Health
 2022-03-23 EARLY_PHASE1
NCT05066633 UNKNOWN
Muscular Dystrophy, Duchenne
Medical University of Gdansk
 2021-08-18 PHASE3
NCT03138603 COMPLETED
Heart Diseases
University of Chicago
 2016-12 PHASE3
NCT06004453 Recruiting
Heart Failure
Novartis Pharmaceuticals|Novartis
 2023-04-04 --
NCT04661709 UNKNOWN
Coronary Heart Disease; Unstable Angina; Chinese Herbal Medicine
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
 2021-03-01 PHASE4
NCT04133532 COMPLETED
Hypertrophic Cardiomyopathy
University Hospital, Motol
 2020-03-05 PHASE4
NCT03689946 COMPLETED
Cardiovascular Disease; Hyperlipidemia
Cedars-Sinai Medical Center
 2019-03-19 PHASE3
NCT05711810 COMPLETED
Severe Acute Respiratory Syndrome-related Coronavirus; Renal Dialysis; Vaccines; Myocarditis Allergic; Infection Viral
Yang I. Pachankis
 2023-01-02 PHASE4
NCT04082910 UNKNOWN
Solid Tumor; Hematological Malignancy
Chinese PLA General Hospital
 2019-09-15 PHASE1; PHASE2
NCT03943927 COMPLETED
Post-operative Atrial Fibrillation
Vanderbilt University Medical Center
 2021-03-05
NCT04457323 UNKNOWN
Hypertension
Neutec Ar-Ge San ve Tic A.Ş
 2022-01-15 PHASE4
NCT05368376 COMPLETED
Hypotension Drug-Induced
Damanhour Teaching Hospital
 2021-04-01 PHASE4
NCT07074834 COMPLETED
Coronary Heart Disease (CHD)
Shiyan City Renmin Hospital
 2021-02-01
NCT05368831 COMPLETED
Healthy Volunteers
NorthSea Therapeutics B.V.
 2022-07-19 PHASE1
NCT04049786 UNKNOWN
Obesity; Bariatric Surgery; Roux-en Y Gastric Bypass
Natalia Valadares de Moraes
 2019-06-01 PHASE4
NCT05368831 Completed
Healthy Volunteers
NorthSea Therapeutics B.V.
 2022-07-19 Phase 1
NCT04513509 COMPLETED
Atrial Fibrillation; Rate Control; Cardiopulmonary Exercise Test
National Taiwan University Hospital
 2020-10-21
NCT05261464 UNKNOWN
Heart Rate; Coronary Computed Tomography Angiography
Mahidol University
 2021-01-30 PHASE4
NCT04504045 TERMINATED
Diabetes Mellitus, Type 2
University of Southern Denmark
 2020-09-01 PHASE1
NCT05768542 COMPLETED
Takotsubo Cardiomyopathy
Danderyd Hospital
 2016-04-12 PHASE1; PHASE2
NCT03008382 COMPLETED
Interstitial Cystitis/Painful Bladder Syndrome; Myofascial Pelvic Pain
Virginia Commonwealth University
 2017-03-01 PHASE4
NCT05171985 Unknown status
COVID-19 Pneumonia|Atrial Fibrillation
Tanta University
 2022-01 Not Applicable
NCT02695992 COMPLETED
Atrial Fibrillation; Permanent Atrial Fibrillation
Asker & Baerum Hospital
 2016-02 PHASE4
NCT04842981 Terminated
Arthritis Rheumatoid|Interaction
University of Southern Denmark|Odense University Hospital|Hospital of South West Jutland|King Christian X´Hospital for Rheumatic Diseases|Sygehus Lillebaelt|Odense Patient Data Explorative Network
 2021-05-25 Phase 1|Phase 2
NCT04713254 COMPLETED
Healthy
H. Lundbeck A/S
 2020-12-08 PHASE1
NCT04425902 COMPLETED
HIV Infections
ViiV Healthcare
 2020-12-16 PHASE1
NCT02123056 UNKNOWN
Vasovagal Syncope
University of Calgary
 2014-10 PHASE4
NCT03082352 UNKNOWN
Healthy
Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited
 2020-08 PHASE1
NCT03845075 COMPLETED
Hypothalamic Injury-induced Obesity (HIO)
Saniona
 2019-02-25 PHASE2
NCT03532802 COMPLETED
Hypertrophic Cardiomyopathy
Steen Hvitfeldt Poulsen
 2018-05-01 PHASE2
NCT03579914 COMPLETED
Anterior Myocardial Infarction; Heart Failure
Harbin Medical University
 2017-11-28
NCT03556592 COMPLETED
Atopic Dermatitis
LEO Pharma
 2018-08-13 PHASE1
NCT03696758 COMPLETED
Infant,Premature
University of Wisconsin, Madison
 2018-10-30 PHASE2
NCT03830957 UNKNOWN
Heart Failure; CT Angiography; Ischemic Cardiomyopathy; Non-ischemic Cardiomyopathy; Heart Failure, Systolic; Heart Failure，Congestive; Heart Failure, Diastolic; Heart Rate Low
Rajaie Cardiovascular Medical and Research Center
 2018-11-26
NCT02587351 TERMINATED
Pulmonary Disease, Chronic Obstructive
University of Minnesota
 2016-05-01 PHASE3
NCT03413410 UNKNOWN
ACS - Acute Coronary Syndrome
Yun Dai Chen
 2018-02-01
NCT03149445 COMPLETED
Confirmed Genetic Diagnosis of Prader-Willi Syndrome
Saniona
 2017-03-30 PHASE2
NCT03488719 COMPLETED
Phase 1
Saniona
 2018-07-11 PHASE1
NCT03384524 WITHDRAWN
Diabetic Macular Edema
Andrew Moshfeghi, MD, MBA
 2018-03 PHASE1; PHASE2
NCT03162120 WITHDRAWN
Atrial Fibrillation; Recurrence
Elpen Pharmaceutical Co. Inc.
 2018-09-01 PHASE2; PHASE3
NCT03072082 UNKNOWN
Coronary Artery Disease(CAD)
Jun Li
 2017-06 PHASE4
NCT02025465 UNKNOWN
Atrial Fibrillation; Atrial Flutter
CAMC Health System
 2013-12 PHASE4
NCT03072121 UNKNOWN
Coronary Artery Disease(CAD)
Jun Li
 2017-06 PHASE4
NCT02248753 COMPLETED
Atrial Fibrillation
Maastricht University Medical Center
 2014-10
NCT02612298 COMPLETED
Essential Hypertension
Marubeni Pharmaceuticals (Suzhou) Co., Ltd.
 2015-08 PHASE4
NCT02417246 COMPLETED
Blood Pressure
University of Florida
 2015-08 PHASE4
NCT03457597 COMPLETED
Healthy
Corcept Therapeutics
 2018-03-06 PHASE1
NCT01837069 TERMINATED
Osteoarthritis; Cardiovascular Disease
NYU Langone Health
 2014-02 PHASE4
NCT03441412 COMPLETED
Healthy Volunteers
Vastra Gotaland Region
 2018-02-28 PHASE1
NCT02269696 WITHDRAWN
Breast Cancer
Kuopio University Hospital
 2018-03-21 PHASE3
NCT03286829 COMPLETED
Healthy Male Subjects
Saniona
 2017-12-18 PHASE1
NCT01970501 COMPLETED
Current or Recent History of Atrial Fibrillation
ARCA Biopharma, Inc.
 2014-04 PHASE2
NCT02513927 UNKNOWN
Hypertension
First Affiliated Hospital of Harbin Medical University
 2015-08 PHASE2; PHASE3
NCT01595516 COMPLETED
Prehypertension; Hypertension
University of Colorado, Boulder
 2012-02 PHASE4
NCT02772354 UNKNOWN
Ventricular Arrhythmia
Meshalkin Research Institute of Pathology of Circulation
 2016-04 PHASE2; PHASE3
NCT02251509 UNKNOWN
Atrial Fibrillation
Creighton University
 2016-12 PHASE4
NCT02293096 TERMINATED
Hypertension
University of Colorado, Denver
 2014-09
NCT02772601 COMPLETED
Psoriasis
AbbVie
 2016-09-15 PHASE1
NCT03103568 COMPLETED
Drug Drug Interaction
Swedish Orphan Biovitrum
 2017-03-28 PHASE1
NCT02408172 UNKNOWN
Sleep Apnea Syndrome; Hypertension
First Affiliated Hospital of Harbin Medical University
 2013-10 PHASE2; PHASE3
NCT02924454 COMPLETED
Drug Overdose; Overdose of Beta-adrenergic Blocking Drug; Blood Pressure
Mikkel Bring Christensen
 2016-09 PHASE4
NCT00223717 COMPLETED
Hypertension
Vanderbilt University
 2001-01 PHASE1
NCT02737891 COMPLETED
Type 2 Diabetes Mellitus
Saniona
 2016-04 PHASE2
NCT02809820 COMPLETED
Acute Coronary Syndrome
Federico II University
 2016-05 PHASE4
NCT02940379 COMPLETED
Type 2 Diabetes Mellitus
Sanofi
 2016-10 PHASE1
NCT01395329 COMPLETED
Prehypertension; Hypertension
University of Colorado, Boulder
 2011-05 PHASE4
NCT02746575 COMPLETED
Adrenergic Beta-Receptor Blockader; Troponin Levels; Cardiomyopathy, Post-surgical
Washington University School of Medicine
 2015-11 PHASE4
NCT02361619 COMPLETED
Healthy Volunteers
Turku University Hospital
 2015-02 PHASE1
NCT02647086 COMPLETED
Atopic Dermatitis
Regeneron Pharmaceuticals
 2015-12 PHASE1
NCT01458600 COMPLETED
Graves´ Disease
Mikael Lantz
 2006-09 PHASE4
NCT02578277 COMPLETED
HIV Infections
ViiV Healthcare
 2015-11-09 PHASE1
NCT01501929 COMPLETED
Hypertension
University of Texas Southwestern Medical Center
 2010-08 PHASE4
NCT01728272 UNKNOWN
Drug Absorption
Kuopio University Hospital
 2012-11
NCT02484859 COMPLETED
Nasal Polyps
Recep Tayyip Erdogan University
 2015-07 PHASE4
NCT00756236 COMPLETED
Myocardial Ischemia
University of Oklahoma
 2008-10
NCT05008250 COMPLETED
Premature Ventricular Contraction
Xuanwu Hospital, Beijing
 2014-01 PHASE4
NCT01901549 UNKNOWN
Acute Coronary Syndrome; Arterial Hypertension
Meshalkin Research Institute of Pathology of Circulation
 2013-06 PHASE2
NCT02029118 COMPLETED
Stable Angina Pectoris
Chengdu University of Traditional Chinese Medicine
 2012-10 EARLY_PHASE1
NCT02012075 UNKNOWN
Heart Failure
Jiangsu HengRui Medicine Co., Ltd.
 2013-12 PHASE3
NCT02254148 COMPLETED
Healthy
Boehringer Ingelheim
 2014-10 PHASE1
NCT01755663 UNKNOWN
Coronary Artery Disease
Col. Suthee Panichkul
 2014-12 PHASE4
NCT01434134 COMPLETED
Breast Cancer; Heart Failure
University Hospital, Akershus
 2011-09 PHASE2
NCT01157572 COMPLETED
Aortic Valve Insufficiency
Oslo University Hospital
 2010-08 PHASE4
NCT01044693 COMPLETED
Hypertension; Pure Autonomic Failure; Multiple System Atrophy
Vanderbilt University
 2010-01
NCT01157234 COMPLETED
Hypertension
University of Florida
 2010-07 PHASE4
NCT01658657 COMPLETED
Hypertension; Plasma Renin Activity
University of North Carolina, Chapel Hill
 2012-10
NCT01499134 COMPLETED
Peripheral Artery Disease; Hypertension
Thomas Jefferson University
 2011-08 PHASE3
NCT01508325 COMPLETED
Hypertension
Merck KGaA, Darmstadt, Germany
 2011-12 PHASE4
NCT02045966 COMPLETED
Hepatitis C
Bristol-Myers Squibb
 2014-02 PHASE1
NCT01203852 COMPLETED
Hypertension
University of Florida
 2010-08 PHASE4
NCT02097511 COMPLETED
Hypertension; Peripheral Artery Disease
Ajou University School of Medicine
 2013-12 PHASE1
NCT01041287 COMPLETED
Hypertension
Emory University
 2009-12 PHASE4
NCT01970059 UNKNOWN
Hypertension
Jiangsu HengRui Medicine Co., Ltd.
 2013-10 PHASE3
NCT01845194 COMPLETED
Drug Biotransformation; Membrane Transport
Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
 2009-12 PHASE1
NCT01902550 WITHDRAWN
Healthy
Janssen Research & Development, LLC
 2013-07 PHASE1
NCT01676285 COMPLETED
Cirrhosis; Cirrhotic Cardiomyopathy; Cardiac Remodeling
University of Sao Paulo
 2012-01 PHASE3
NCT01441570 TERMINATED
Transplant; Failure, Kidney; Hypertension
Brigham and Women's Hospital
 2012-02
NCT01917149 COMPLETED
Dilated Cardiomyopathy
Xijing Hospital
 2005-03 PHASE4
NCT01281787 COMPLETED
Lung Cancer; Atrial Fibrillation
European Institute of Oncology
 2008-04 PHASE3
NCT01884857 COMPLETED
Fasting
IPCA Laboratories Ltd.
 2013-04 PHASE1
NCT01502787 COMPLETED
Hypertension
University of Texas Southwestern Medical Center
 2009-04 PHASE4
NCT01884909 COMPLETED
Fed
IPCA Laboratories Ltd.
 2013-04 PHASE1
NCT00995072 COMPLETED
Hypertension; Female Sexual Dysfunction
East Coast Institute for Research
 2009-10
NCT01605370 TERMINATED
Hypertension
Mayo Clinic
 2012-06 PHASE4
NCT01585623 COMPLETED
Solid Tumor
Bristol-Myers Squibb
 2012-06 PHASE1
NCT01884896 COMPLETED
Fasting
IPCA Laboratories Ltd.
 2013-02 PHASE1
NCT01311700 COMPLETED
Myocardial Infarction
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
 2010-11 PHASE4
NCT03882710 COMPLETED
Diastolic Heart Failure
Post Graduate Institute of Medical Education and Research, Chandigarh
 2010-01 PHASE2
NCT01523002 COMPLETED
Malaria
Medicines for Malaria Venture
 2012-01 PHASE1
NCT01049009 COMPLETED
High Blood Pressure
Emory University
 2009-12 PHASE4
NCT01659944 COMPLETED
Healthy
Genzyme, a Sanofi Company
 2012-05 PHASE1
NCT00806390 TERMINATED
Cardiomyopathy
University of Maryland, Baltimore
 2008-07 PHASE4
NCT01863173 COMPLETED
B Thalassemia
Shiraz University of Medical Sciences
 2012-01 PHASE2; PHASE3
NCT00829296 COMPLETED
Hypertension; Diabetes
University of Chicago
 2009-01 PHASE2; PHASE3
NCT01330654 WITHDRAWN
Cardiac Event Risk
University of California, San Francisco
 2011-03
NCT00992056 COMPLETED
Hypertension
University of Miami
 2010-12 PHASE4
NCT00585871 WITHDRAWN
Ventricular Tachycardia
James Martins
 2006-05
NCT00605072 COMPLETED
Cognitive Impairment; Hypertension; Aging
University of Southern California
 2008-01 PHASE2
NCT01029223 WITHDRAWN
Blood Pressure
Bayside Health
 2008-10 PHASE4
NCT01655303 COMPLETED
Rapid Ventricular Response Atrial Fibrillation
Tehran University of Medical Sciences
 2011-02 PHASE4
NCT00825123 TERMINATED
Central Arterial Pressure
Bayside Health
 2008-10 PHASE4
NCT01337674 COMPLETED
Hypertension
Merck Sharp & Dohme LLC
 2011-04-01 PHASE1
NCT01213173 COMPLETED
Angina Pectoris
AstraZeneca
 2010-10 PHASE4
NCT01324388 COMPLETED
Diabetes Mellitus, Type 2
Eli Lilly and Company
 2011-03 PHASE1
NCT00775671 COMPLETED
Metabolic Syndrome
Vanderbilt University
 2008-10 PHASE4
NCT00401882 TERMINATED
Cardiac Arrest; Sudden Cardiac Death; Ventricular Fibrillation; Tachycardia, Ventricular
David Haines, MD
 2007-01 PHASE2
NCT03635125 COMPLETED
JNC 7 Stage 1 or 2 Hypertension
Trinity Hypertension & Metabolic Research Institute
 2010-08-30 PHASE4
NCT01404767 TERMINATED
Vascular Disease; Hypertension; Angina; Cardiac Disease
University Health Network, Toronto
 2011-04 PHASE4
NCT01187862 COMPLETED
Cytochrome; Pharmacokinetics
University Hospital, Basel, Switzerland
 2010-07 PHASE1
NCT01673997 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2010-12 PHASE1
NCT01694797 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2011-01 PHASE1
NCT00999102 COMPLETED
Hypertension
Weill Medical College of Cornell University
 2009-10 PHASE4
NCT00865917 UNKNOWN
Postural Orthostatic Tachycardia Syndrome
Hannover Medical School
 2008-11 PHASE2
NCT01914926 COMPLETED
Heart Rate and Rhythm Disorders
Antonios Likourezos
 2009-06 PHASE4
NCT00849810 TERMINATED
Hypertension
University of Mississippi Medical Center
 2009-01
NCT01211821 COMPLETED
Atrial Fibrillation
Bristol-Myers Squibb
 2010-09 PHASE1
NCT01238705 UNKNOWN
Hypertension; Sexual Dysfunction
LanZhou University
 2008-04 PHASE4
NCT00313157 COMPLETED
Atrial Fibrillation
Asker & Baerum Hospital
 2006-04 PHASE3
NCT01052428 COMPLETED
Mitral Regurgitation
University of Alabama at Birmingham
 2004-08 PHASE2; PHASE3
NCT00744237 COMPLETED
Hypertension; Type 2 Diabetes Mellitus
Forest Laboratories
 2008-08 PHASE4
NCT00993421 TERMINATED
Obesity
Eli Lilly and Company
 2009-10 PHASE2
NCT00627861 TERMINATED
Hypertension
The Rogosin Institute
 2008-11
NCT01051947 WITHDRAWN
Central Aortic Pressure
Creighton University
 2009-12
NCT00783900 COMPLETED
Atrial Fibrillation; Biatrial Pacing; Metoprolol
Kuopio University Hospital
 2007-01 PHASE4
NCT00563238 WITHDRAWN
Myocardial Ischemia
Gregory A. Schmidt
 2007-11
NCT00661895 COMPLETED
Hypertension
Creighton University
 2005-08 PHASE4
NCT00885651 UNKNOWN
Heart Failure
Rigshospitalet, Denmark
 2008-09 PHASE4
NCT00292162 COMPLETED
Chronic Heart Failure; Atrial Fibrillation
NHS Greater Glasgow and Clyde
 2007-01
NCT00784316 COMPLETED
Atrial Fibrillation; Cardiac Surgery
Kuopio University Hospital
 2007-08 PHASE4
NCT00648895 COMPLETED
Hypertension
Forest Laboratories
 2007-11 PHASE3
NCT00433043 TERMINATED
Congestive Heart Failure
St. Luke's-Roosevelt Hospital Center
 2007-01 PHASE4
NCT01798992 COMPLETED
Idiopathic Dilated Cardiomyopathy
University of Colorado, Denver
 2000-09 PHASE4
NCT00491387 TERMINATED
Hypertension
University of Cincinnati
 2007-08 PHASE4
NCT00391846 COMPLETED
Heart Failure; Ventricular Dysfunction, Left
AstraZeneca
 2006-10 PHASE4
NCT00942487 COMPLETED
Primary Arterial Hypertension
Berlin-Chemie Menarini
 2005-04 PHASE3
NCT01248338 COMPLETED
Hypertension
Berlin-Chemie AG Menarini Group
 2006-03 PHASE4
NCT00732511 UNKNOWN
Endothelial Function; Diabetes Mellitus; Hypertension
State University of New York - Downstate Medical Center
 2008-04 PHASE4
NCT00642434 COMPLETED
Diabetes
University of New Mexico
 2004-01 PHASE4
NCT03370835 COMPLETED
Pulmonary Disease, Chronic Obstructive; Asthma; Adverse Effect of Beta-adrenoreceptor Antagonists
VA Greater Los Angeles Healthcare System
 2004-06 PHASE4
NCT00384566 WITHDRAWN
Heart Failure; Chronic Obstructive Airway Disease
The Alfred
 2005-06 PHASE4
NCT00142584 COMPLETED
Hypertension
Mylan Bertek Pharmaceuticals
 2005-08 PHASE3
NCT00547300 TERMINATED
Hypertension
Forest Laboratories
 2007-10-31 PHASE3
NCT00273052 COMPLETED
Hypertension
GlaxoSmithKline
 2006-01-05 PHASE3
NCT00226096 COMPLETED
CVA (Cerebrovascular Accident); Cerebral Hemorrhage; Intracranial Hemorrhages
The George Institute
 2005-11
NCT00166400 COMPLETED
Heart Valve Diseases
Mayo Clinic
 2004-07 PHASE4
NCT00182039 TERMINATED
Cardiovascular Diseases
Hamilton Health Sciences Corporation
 2002-10 PHASE3
NCT00123604 COMPLETED
Hypertension; Type 2 Diabetes Mellitus
St. Paul Heart Clinic
 2004-06 PHASE4
NCT02336607 COMPLETED
Hypertension
AstraZeneca
 2005-12
NCT00123903 TERMINATED
Heart Failure, Congestive and Microalbuminuria
GlaxoSmithKline
 2005-07 PHASE3
NCT00861016 COMPLETED
Hypertension
AstraZeneca
 2005-10 PHASE4
NCT00152633 WITHDRAWN
Hypertension
University of Erlangen-Nürnberg Medical School
 2005-09 PHASE2; PHASE3
NCT00077948 TERMINATED
Heart Failure, Congestive
Gilead Sciences
 2003-07 PHASE3
NCT00802230 COMPLETED
Heart Failure
University of Utah
 2002-09 PHASE4
NCT02242812 TERMINATED
Hypertension
Boehringer Ingelheim
 2003-09 PHASE4
NCT00642096 COMPLETED
High Blood Pressure (Hypertension).
AstraZeneca
 2003-06 PHASE3
NCT00060931 COMPLETED
Hypertension
GlaxoSmithKline
 2001-06 PHASE4
NCT00060918 COMPLETED
Hypertension
GlaxoSmithKline
 2001-06 PHASE4
NCT00679653 COMPLETED
Obesity; Hypertension
Abbott
 2002-02 PHASE3
NCT02264002 COMPLETED
Healthy
Boehringer Ingelheim
 2003-02 PHASE1
NCT00649233 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2003-01 PHASE1
NCT00649688 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2003-01 PHASE1
NCT00649116 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2002-12 PHASE1
NCT00648271 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2002-12 PHASE1
NCT01478490 COMPLETED
Pharmacokinetics of Mirabegron; Healthy Subjects
Astellas Pharma Inc
 2002-09 PHASE1
NCT01523054 COMPLETED
Acute Myocardial Infarction
AstraZeneca
 2000-02 PHASE1
NCT04364139 COMPLETED
Hypertensive Nephrosclerosis; Chronic Renal Insufficiency
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 1995-02-01 PHASE3
NCT00222573 COMPLETED
Acute Myocardial Infarction
University of Oxford
 1999-07 PHASE4
NCT00718406 COMPLETED
Acute Coronary Syndromes
Sahlgrenska University Hospital
 PHASE4
NCT00302692 UNKNOWN
Multiple Trauma; Cardiovascular Diseases; Aged
University of Texas Southwestern Medical Center
 2005-12 PHASE2
NCT00255528 COMPLETED
Hypertension
AstraZeneca
 2002-07 PHASE3
NCT00288548 UNKNOWN
Chronic Obstructive Pulmonary Disease (COPD)
Martini Hospital Groningen
 2006-02 PHASE4
NCT00930306 COMPLETED
Chronic Pain
AstraZeneca
 2009-06 PHASE1
NCT00255502 COMPLETED
Hypertension
AstraZeneca
 2002-07 PHASE3
NCT00198614 COMPLETED
Coronary Disease; Atrial Fibrillation
Ministry of Health, Labour and Welfare, Japan
 2005-01
NCT00475462 COMPLETED
Syncope, Vasovagal
Peking University First Hospital
 2001-07
NCT00497003 COMPLETED
Endothelial Function; Beta Blocker
Bispebjerg Hospital
 2004-02 PHASE4
NCT00000499 COMPLETED
Cardiovascular Diseases; Heart Diseases; Hypertension; Vascular Diseases
National Heart, Lung, and Blood Institute (NHLBI)
 1980-09 PHASE2
NCT00819104 COMPLETED
Primary Hypertension
AstraZeneca
 2008-11 PHASE4
NCT00214318 COMPLETED
Heart Failure
University of Wisconsin, Madison
 2005-01

(data from https://clinicaltrials.gov, updated on 2025-09-18)

Check the Metoprolol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Metoprolol selectively binds to and inhibits cardioselective β1-adrenergic receptors, blocking catecholamine-mediated activation of adenylate cyclase and the downstream cyclic AMP signaling cascade in cardiac cells. This receptor blockade decreases heart rate, myocardial contractility, and cardiac output, providing clinical utility in reducing blood pressure and managing conditions such as heart failure, hypertension, and atrial fibrillation.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.