CAS No. 22664-55-7
Batch:
Purity:99.18
Chemical Structure
Check the
Metipranolol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 22664-55-7 | |
|---|---|---|
| Molecular Formula |
C17H27NO4 |
|
| Molecular Weight (MW) | 309.4 | |
| SMILES | CC(C)NCC(O)COC1=CC(=C(OC(C)=O)C(=C1C)C)C |
Biological Activity
Metipranolol is a potent, non-selective β-adrenergic receptor antagonist, possessing high beta-blocking potencies at guinea pig atrial β1-adrenoceptors (pA2 8.3) and rat uterine β2-adrenoceptors (pA2 8.4). Competitive blockade of these β-adrenoceptor subtypes suppresses adrenoceptor-mediated G-protein signaling pathways and downregulates downstream intracellular cAMP generation, ultimately leading to reduced aqueous humor formation and lowered intraocular pressure. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 62 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.