CAS No. 54522-52-0

Batch: Purity:98
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Methylprotodioscin Chemical Structure
Chemical Structure
Check the Methylprotodioscin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 54522-52-0
Molecular Formula

C52H86O22
Molecular Weight (MW) 1063.23
SMILES CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)OC

Biological Activity

Methylprotodioscin is a natural steroidal saponin isolated from Dioscorea collettii Makino that displays potent anticancer and anti-inflammatory activities. It modulates cell cycle regulatory pathways to induce G2/M phase arrest and trigger apoptotic cell death in human cancer cell lines. Furthermore, it attenuates pro-inflammatory responses and lipid accumulation, resulting in suppressed tumor cell proliferation and survival.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (94.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 2 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.