CAS No. 2375-03-3

Batch: Purity:99.02
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Methylprednisolone sodium succinate Chemical Structure
Chemical Structure
Check the Methylprednisolone sodium succinate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium 4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
CAS Number 2375-03-3
Molecular Formula

C26H33NaO8
Molecular Weight (MW) 496.53
SMILES CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)[O-])O.[Na+]
InChIKey FQISKWAFAHGMGT-SGJOWKDISA-M

Ordering Information

Biological Activity

Methylprednisolone sodium succinate is a synthetic corticosteroid and glucocorticoid receptor agonist that exhibits anti-inflammatory and immunosuppressive activities. Upon binding, the activated glucocorticoid receptor translocates to the nucleus to regulate target gene transcription and suppress NF-κB-mediated signaling pathways. Consequently, this suppresses the expression of pro-inflammatory cytokines and inflammatory mediators, leading to inhibited immune cell activation and reduced cellular inflammatory responses. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (201.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.