CAS No. 73232-52-7

Batch: Purity:99.15
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methylnaltrexone bromide Chemical Structure
Chemical Structure
Check the methylnaltrexone bromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7-one bromide
CAS Number 73232-52-7
Molecular Formula

C21H26NO4.Br
Molecular Weight (MW) 436.34
InChIKey IFGIYSGOEZJNBE-KNLJMPJLSA-N

Ordering Information

Biological Activity

Methylnaltrexone bromide functions as a targeted antagonist of the µ-opioid receptor. Blockade of receptor signaling by methylnaltrexone bromide inhibits Src kinase phosphorylation and downstream STAT3, PI3K, and Akt activation pathways. Consequently, this pathway inhibition suppresses growth factor-induced epithelial-mesenchymal transition, restricts cell migration, and significantly reduces the proliferation and viability of human non-small cell lung cancer cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (229.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.