Methyl Eugenol SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Methyl Eugenol
CAS Number: 93-15-2
PubChem CID: 7127
Molecular formula: C11H14O2
Molecular weight: 178.23 g/mol
IUPAC name: 1,2-dimethoxy-4-prop-2-enylbenzene

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to t
Skin contact: SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Eye contact: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Ingestion: INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Fires involving this material can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Use alcohol foam

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
Flash point: 210 °F (NTP, 1992)

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

7.1 Precautions for safe handling
SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it under ambient temperatures. (NTP, 1992)

7.2 Conditions for safe storage, including any incompatibilities
Store in a cool, dry, well-ventilated area. Keep container tightly closed.
Store away from incompatible materials (see Section 10).
Protect from light and moisture.
Recommended storage (industry convention for research compounds): -20°C for long-term storage; 2-8°C for short-term use and transport.
[Note: This is a general industry recommendation. Always verify exact storage conditions with the supplier Certificate of Analysis (COA).]
Store in original container. Keep upright to prevent leakage.

9.1 Information on basic physical and chemical properties
a) Appearance: Methyleugenol is a clear colorless to pale yellow liquid with a spicy earthy odor. Bitter burning taste. (NTP, 1992)
b) Odor: Mild-spicy, slightly herbal odor
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 25 °F (NTP, 1992)
f) Initial boiling point and boiling range: 490.5 °F at 760 mmHg (NTP, 1992)
g) Flash point: 210 °F (NTP, 1992)
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 0.02 mmHg at 68 °F ; 1 mmHg at 185.0 °F (NTP, 1992)
l) Vapor density: No data available
m) Relative density: 1.0396 at 68 °F (NTP, 1992) - Denser than water; will sink
n) Water solubility: less than 1 mg/mL at 66 °F (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): 2.5
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 18.5 Ų
Complexity: 156

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
No data available.
Respiratory or skin sensitization:
May cause an allergic skin reaction (H317).
Germ cell mutagenicity:
Suspected of causing genetic defects (H341).
Carcinogenicity:
May cause cancer (H350).
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
H373
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Carcinogen classification:
Methyleugenol
Group 2A: Probably carcinogenic to humans
Volume 101: (2012) Some Chemicals Present in Industrial and Consumer Products, Food and Drinking-water
Volume 134: (2024) Aspartame, Methyleugenol, and Isoeugenol
2024 online
2023
Methyleugenol
TR-491: Toxicology and Carcinogenesis Studies of Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (2000 )
10/30/98
Clear Evidence
Clear Evidence
Clear Evidence
Clear Evidence
Under the conditions of these 2-year gavage s
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
LC50 Lepomis macrochirus (Bluegill) 8.5 mg/L/24 hr; static /formulated product/
LC50 Lepomis macrochirus (Bluegill) 8.1 mg/L/48 hr (95% confidence interval: 7.4-9.0 mg/L); static /formulated product/
LC50 Lepomis macrochirus (Bluegill) 8.1 mg/L/96 hr (95% confidence interval: 7.4-9.0 mg/L); static /formulated product/
LC50 Oncorhynchus mykiss (Rainbow trout, donaldson trout) >5.6-<10 mg/L/24 hr; static /formulated product/
For more Ecotoxicity Values (Complete) data for METHYLEUGENOL (6 total), please visit the HSDB record page.
/FIELD STUDIES/ Field trapping of fruit flies by using methyl eugenol over 5 wk period was conducted in orchard in Gombak, Selangor. Traps with slit holes caught greatest number of flies. Over 85% of flies caught were male, Dacus dorsalis.
Methyleugenol's production as a flavoring agent and in perfumery, may result in its release to the environment through various waste streams; it's use as an insect attractant will result in its direct release to the environment. Methyleugenol was identified as a volatile flavor compound in the juice of Kogyoku apples and occurs as a component of rose oil and pimento oil. If released to air, a vapor pressure of 0.012 mm Hg at 25 °C indicates methyleugenol will exist almost entirely as a vapor. Vapor-phase methyleugenol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 5 hours. If released to soil, methyleugenol is

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): 2.5
Low potential for bioaccumulation (Log P < 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).
DOT label: Poison

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard
Environmental hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Benzene, 1,2-dimethoxy-4-(2-propenyl)-
- California Safe Cosmetics Program (CSCP) Reportable Ingredient: Hazard Traits - Carcinogenicity Authoritative List - IARC Carcinogens - 2A; NTP RoC - reasonable; Prop 65 Report - regardless of intended function of ingredient in the product
- EFSA Legal Basis: Regulation (EC) No 1831/2003 (amended)
- New Jersey Worker and Community Right to Know Act: The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
- FIFRA Requirements: Methyl eugenol and malathion combination; exemption from the requirement of a tolerance. The insect attractant methyl eugenol and the insecticide malathion are exempt from the requirement of tolerances on all raw agricultural commodities when used in combination in Oriental fruit fly eradication pro

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/10
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.