CAS No. 99-76-3

Batch: Purity:99.95
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Methyl 4-hydroxybenzoate Chemical Structure
Chemical Structure
Check the Methyl 4-hydroxybenzoate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl 4-hydroxybenzoate
CAS Number 99-76-3
Molecular Formula

C8H8O3
Molecular Weight (MW) 152.15
SMILES COC(=O)C1=CC=C(C=C1)O
InChIKey LXCFILQKKLGQFO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Methyl 4-hydroxybenzoate (Methylparaben) is a widely used antifungal and antimicrobial agent that serves as a preservative in food and personal-care products. It exerts antifungal activity by disrupting cell membrane integrity, altering membrane transport mechanisms, and inhibiting cellular respiration in fungi. In mammalian systems, methylparaben also demonstrates weak estrogenic activity by binding to estrogen receptors, modulating downstream estrogenic signaling and gene transcription. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (197.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.