CAS No. 13031-60-2

Batch: Purity:99
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Methyl 4-aminobutyrate HCl Chemical Structure
Chemical Structure
Check the Methyl 4-aminobutyrate HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 13031-60-2
Molecular Formula

C5H12ClNO2
Molecular Weight (MW) 153.61
SMILES COC(=O)CCCN.Cl

Biological Activity

Methyl 4-aminobutyrate HCl (GABA methyl ester) is a functional derivative and ester prodrug of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It modulates GABAergic signaling pathways by delivering GABA into central nervous system tissues following metabolic cleavage. Enhanced activation of GABA receptors leads to hyperpolarization of neuronal membranes and inhibition of neurotransmitter release, thereby regulating synaptic plasticity, neuronal excitability, and central nervous system homeostasis. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (195.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Olsen RW, et al. Pharmacol Rev. 2008;60(3):243-60.

[2] Johnston GA. Curr Pharm Des. 2005;11(15):1867-85.

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Note: Technical data last updated: Sep 1, 2026.