CAS No. 1206801-37-7
Chemical Structure
Check the
Merestinib dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide;dihydrochloride | |
|---|---|---|
| CAS Number | 1206801-37-7 | |
| Molecular Formula |
C30H24Cl2F2N6O3 |
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| Molecular Weight (MW) | 625.45 | |
| SMILES | [H]Cl.[H]Cl.O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3 | |
| InChIKey | NNYNNMGUBHQQLZ-UHFFFAOYSA-N |
Merestinib dihydrochloride is an orally bioavailable multi-kinase inhibitor targeting c-Met (Ki 2 nM), AXL (IC50 2 nM), DDR1, DDR2, FLT3, MERTK, MST1R, and TEK. It blocks receptor phosphorylation, suppressing downstream MET, AKT, and ERK signaling pathways. This inhibition reduces tumor cell proliferation, migration, and invasion, demonstrating potent antitumor activity in xenograft models. [1]
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- Merestinib dihydrochloride Solubility in DMSO
- Merestinib dihydrochloride Stock Solution
- Merestinib dihydrochloride Storage
- Merestinib dihydrochloride Stability
- Merestinib dihydrochloride Molecular Weight
- Merestinib dihydrochloride SMILES
- Merestinib dihydrochloride Chemical Structure (2D and 3D)
- Merestinib dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.