CAS No. 50-12-4
Batch:
Purity:99.50
Chemical Structure
Check the
Mephenytoin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione | |
|---|---|---|
| CAS Number | 50-12-4 | |
| Molecular Formula |
C12H14N2O2 |
|
| Molecular Weight (MW) | 218.25 | |
| InChIKey | GMHKMTDVRCWUDX-UHFFFAOYSA-N |
Mephenytoin is a hydantoin-derivative antiepileptic drug that acts as a selective probe substrate for evaluating the metabolic activity of cytochrome P450 enzymes, particularly CYP2B6 and CYP2C19. It undergoes stereospecific metabolism, including CYP2C19-mediated 4'-hydroxylation, to modulate drug disposition and clearance pathways. Additionally, mephenytoin is utilized in antimalarial research to investigate metabolic interactions and pharmacokinetic profiles. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
44 mg/mL
(201.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 44 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.