CAS No. 1616359-00-2

Batch: Purity:99.44
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MEN1703(SEL24,SEL24-B489) Chemical Structure
Chemical Structure
Check the MEN1703(SEL24,SEL24-B489) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5,6-dibromo-4-nitro-2-piperidin-4-yl-1-propan-2-ylbenzimidazole
CAS Number 1616359-00-2
Molecular Formula

C15H18Br2N4O2
Molecular Weight (MW) 446.14
InChIKey UOUBCIJIWDLRGM-UHFFFAOYSA-N

Biological Activity

MEN1703 (SEL24) is a potent, orally active dual inhibitor of PIM1 (Kd 2 nM), PIM2 (Kd 2 nM), PIM3 (Kd 3 nM), and FLT3 kinase. By blocking both PIM and FLT3 signaling pathways, it suppresses downstream phosphorylation of STAT5 and 4E-BP1, inhibiting cell proliferation and inducing apoptosis in acute myeloid leukemia models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (199.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.