CAS No. 1922153-17-0 (free base)

Batch: Purity:98.91
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MELK-8a Dihydrochloride Chemical Structure
Chemical Structure
Check the MELK-8a Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-methyl-4-[4-[4-[3-(piperidin-4-ylmethoxy)-4-pyridinyl]pyrazol-1-yl]phenyl]piperazine
CAS Number 1922153-17-0 (free base)
Molecular Formula

C25H34Cl2N6O
Molecular Weight (MW) 505.48
SMILES CN1CCN(CC1)C2=CC=C(C=C2)N3C=C(C=N3)C4=C(C=NC=C4)OCC5CCNCC5
InChIKey BLFBSGVUERKSST-UHFFFAOYSA-N

Biological Activity

MELK-8a Dihydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK). By suppressing MELK activity, the compound disrupts downstream signaling cascades involved in cell cycle progression and cell survival. Consequently, MELK inhibition impairs cellular proliferation, induces cell cycle arrest at the G2/M phase, and promotes apoptotic cell death across various cancer cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 22 mg/mL
DMSO 3 mg/mL (5.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Chung S, et al. Oncotarget. 2012;3(12):1629-40.

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Note: Technical data last updated: Sep 1, 2026.