CAS No. 2250156-71-7(free base)

Batch: Purity:99.09
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MEISi-2 Dihydrochloride Chemical Structure
Chemical Structure
Check the MEISi-2 Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2250156-71-7(free base)
Molecular Formula

C18H14N2O3
Molecular Weight (MW) 306.32

Biological Activity

MEISi-2 Dihydrochloride is a small-molecule inhibitor targeting MEIS transcription factors that significantly represses MEIS-mediated luciferase reporter activity in vitro. By inhibiting MEIS-dependent transcriptional activity, this compound modulates downstream target gene networks regulated by TALE homeobox transcription factors, ultimately disrupting cellular pathways that govern cell cycle progression, cell proliferation, and lineage differentiation phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Mahmoud AI, et al. Nature. 2013;497(7448):249-253.

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Note: Technical data last updated: Sep 1, 2026.