CAS No. 4376-20-9
Batch:
Purity:99.04
Chemical Structure
Check the
MEHP
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(2-ethylhexoxycarbonyl)benzoic acid | |
|---|---|---|
| CAS Number | 4376-20-9 | |
| Molecular Formula |
C16H22O4 |
|
| Molecular Weight (MW) | 278.34 | |
| InChIKey | DJDSLBVSSOQSLW-UHFFFAOYSA-N |
MEHP (Phthalic acid mono-2-ethylhexyl ester) is a phthalate metabolite and a competitive inhibitor of cytochrome P2C9 (CYP2C9) with an IC50 value of 6.37 μM. By inhibiting CYP2C9 activity, MEHP alters hepatic drug metabolism pathways and drug clearance mechanisms. Inhibition of CYP2C9 impairs xenobiotic oxidation, leading to decreased metabolic biotransformation and potentially altering downstream toxicological responses and endocrine homeostasis. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(359.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.