CAS No. 53230-10-7
Batch:
Purity:99.64
Chemical Structure
Check the
Mefloquine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol | |
|---|---|---|
| CAS Number | 53230-10-7 | |
| Molecular Formula |
C17H16F6N2O |
|
| Molecular Weight (MW) | 378.31 | |
| InChIKey | XEEQGYMUWCZPDN-UHFFFAOYSA-N |
Mefloquine is a quinoline antimalarial drug and potassium channel antagonist. By inhibiting voltage-gated cardiac potassium channels, Mefloquine disrupts repolarizing currents and prolongs cardiac repolarization. Furthermore, Mefloquine acts as a potent inhibitor of intercellular gap junction channels, suppressing junctional conductance in neural and vascular tissues. Together, these target interactions influence cellular electrophysiology and contribute to the broad pharmacological profile of Mefloquine in biological systems. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.