CAS No. 51773-92-3
Batch:
Purity:99.99
Chemical Structure
Check the
Mefloquine HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 51773-92-3 | |
|---|---|---|
| Molecular Formula |
C17H17ClF6N2O |
|
| Molecular Weight (MW) | 414.77 | |
| SMILES | C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl |
Biological Activity
Mefloquine HCl is an antimalarial drug and blood schizonticide that acts by inhibiting hemozoin formation in Plasmodium parasites. It targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis and selectively blocks Cx36 and Cx50 gap junction channels. Through the inhibition of ribosomal translation and disruption of intercellular connexin signaling pathways, Mefloquine HCl suppresses parasite survival and alters cellular communication. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 83 mg/mL |
| DMSO |
50 mg/mL
(120.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | 83 mg/mL |
| DMSO |
41 mg/mL
(98.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| DMSO |
82 mg/mL
(197.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 82 mg/mL |
| Water | Insoluble |
| DMSO |
83 mg/mL
(200.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 83 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.