CAS No. 86347-15-1
Batch:
Purity:99.92
Chemical Structure
Check the
Medetomidine HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 86347-15-1 | |
|---|---|---|
| Molecular Formula |
C13H16N2.HCl |
|
| Molecular Weight (MW) | 236.74 | |
| SMILES | CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C.Cl |
Medetomidine HCl is a highly selective α2-adrenoceptor agonist with a Ki of 1.08 nM, exhibiting 1620-fold selectivity over the α1-adrenoceptor. Activation of α2-adrenoceptors inhibits adenylate cyclase, resulting in decreased intracellular cAMP levels and reduced presynaptic norepinephrine release. This inhibition impairs central sympathetic output, leading to potent sedative, hypnotic, and analgesic phenotypes in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 47 mg/mL |
| Ethanol | 47 mg/mL |
| DMSO |
12 mg/mL
(50.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.