Mechlorethamine HCl

Catalog No.S4252

Mechlorethamine HCl Chemical Structure

Molecular Weight(MW): 192.51

Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.

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Biological Activity

Description Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
Targets
DNA synthesis [1]
In vitro

Mechlorethamine is much less toxic to rat hepatocytes under nitrogen and causes much less lipid peroxidation than under aerobic conditions. [1] Mechlorethamine markedly inhibits cell growth and leads to cell detachment associated with rearrangement of the cytoskeletal proteins in rabbit tracheal primary cultures. Mechlorethamine results in early lipid peroxidation and cellular membrane damage in rabbit tracheal primary cultures, this is correlated with a significant increase in the activities of antioxidant enzymes associated with an increase in glutathione content. [2]

In vivo Mechlorethamine (1.5 mg/kg i.v.) reduces mean leukocyte count from 6,320 mm3 to 1,890 mm3 without any change in the leukocyte differential or erythrocyte and platelet counts in rabbits. [3] Mechlorethamine (0.005 mg-0.5 mg, i.d.) causes dose-dependent skin ulcers in the mouse, and isotonic sodium thiosulfate (0.167 M) or hypertonic (0.34 M) (0.05 mL) given immediately after Mechlorethamine significantly reduces the mean HN2 ulceration area and the total time of ulceration. [4]

Protocol

Solubility (25°C)

In vitro DMSO 39 mg/mL (202.58 mM)
Water 39 mg/mL (202.58 mM)
Ethanol 39 mg/mL (202.58 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 192.51
Formula

C5H11Cl2N.HCl

CAS No. 55-86-7
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID