CAS No. 826-39-1
Batch:
Purity:99.94
Chemical Structure
Check the
Mecamylamine Hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 826-39-1 | |
|---|---|---|
| Molecular Formula |
C11H21N.ClH |
|
| Molecular Weight (MW) | 203.75 | |
| SMILES | Cl.CNC1(C)C2CCC(C2)C1(C)C |
Mecamylamine hydrochloride is an orally active, nonselective, and noncompetitive nicotinic acetylcholine receptor (nAChR) antagonist. As a centrally active ganglionic blocker, it readily crosses the blood-brain barrier to modulate cholinergic neurotransmission. By inhibiting nAChR-mediated signaling pathways, mecamylamine alters downstream neuronal and autonomic responses, making it a valuable tool in research on neuropsychiatric disorders, hypertension, and depression-like behavioral phenotypes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 50 mg/mL |
| DMSO |
41 mg/mL
(201.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Mecamylamine Hydrochloride Solubility in DMSO
- Mecamylamine Hydrochloride Stock Solution
- Mecamylamine Hydrochloride Storage
- Mecamylamine Hydrochloride Stability
- Mecamylamine Hydrochloride Molecular Weight
- Mecamylamine Hydrochloride SMILES
- Mecamylamine Hydrochloride Chemical Structure (2D and 3D)
- Mecamylamine Hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.